Secondary central nervous system lymphoma surrounding a region injured by subarachnoid hemorrhage and subsequent aneurysmal clipping

Murata,Yoriko; Hata,Yasuhiro; Noda,Yoshihiro; Matsusaka,Satoshi; Fukui,Naoki; Kadota,Tomohito; Iwata,Jun; Machida,Takuya; Yamagami,Takuji

doi:10.3892/br.2017.981

Secondary central nervous system lymphoma surrounding a region injured by subarachnoid hemorrhage and subsequent aneurysmal clipping

Authors:
- Yoriko Murata
- Yasuhiro Hata
- Yoshihiro Noda
- Satoshi Matsusaka
- Naoki Fukui
- Tomohito Kadota
- Jun Iwata
- Takuya Machida
- Takuji Yamagami
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Affiliations: Department of Radiology, Kochi Medical School, Kochi 7838505, Japan, Department of Radiology, Kochi Health Sciences Center, Kochi 7818555, Japan, Department of Neurosurgery, Kochi Medical School, Kochi 7838505, Japan, Department of Pathology, Kochi Health Sciences Center, Kochi 7818555, Japan, Department of Hematology and Transfusion Medicine, Kochi Health Sciences Center, Kochi 7818555, Japan
Published online on: September 11, 2017 https://doi.org/10.3892/br.2017.981
Pages: 474-476

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Abstract

The present case study describes a rare case of secondary central nervous system (CNS) lymphoma that infiltrated the dura and leptomeninges around the area injured by subarachnoid hemorrhage and subsequent aneurysmal clipping. Invasion of the CNS was observed by computed tomography as slurred fissures of the right parietal lobe adjacent to the surgery area. Subdural and subarachnoid enhancement overlapping the area injured by past surgical procedures was observed by contrast‑enhanced magnetic resonance imaging. Surgical resection revealed B-cell lymphoma infiltrating the dura and leptomeninges surrounding the post‑hemorrhagic area. The patient was subsequently diagnosed with systemic lymphoma and bone marrow invasion, and multiple lymph node swelling. To the best of our knowledge, this is the first report of malignant lymphoma involving the CNS overlapping a previously injured area.

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1	Haldorsen IS, Espeland A and Larsson EM: Central nervous system lymphoma: Characteristic findings on traditional and advanced imaging. AJNR Am J Neuroradiol. 32:984–992. 2011. View Article : Google Scholar : PubMed/NCBI
2	Koeller KK, Smirniotopoulos JG and Jones RV: Primary central nervous system lymphoma: Radiologic-pathologic correlation. Radiographics. 17:1497–1526. 1997. View Article : Google Scholar : PubMed/NCBI
3	Hill QA and Owen RG: CNS prophylaxis in lymphoma: Who to target and what therapy to use. Blood Rev. 20:319–332. 2006. View Article : Google Scholar : PubMed/NCBI
4	Aho R, Vaittinen S, Jahnukainen K and Kalimo H: Spread of malignant lymphoid cells into rat central nervous system with intact and disrupted blood-brain barrier. Neuropathol Appl Neurobiol. 20:551–561. 1994. View Article : Google Scholar : PubMed/NCBI
5	Guermazi A, Lafitte F, Miaux Y, Adem C, Bonneville JF and Chiras J: The dural tail sign-beyond meningioma. Clin Radiol. 60:171–188. 2005. View Article : Google Scholar : PubMed/NCBI
6	Stuckey SL, Goh TD, Heffernan T and Rowan D: Hyperintensity in the subarachnoid space on FLAIR MRI. AJR Am J Roentgenol. 189:913–921. 2007. View Article : Google Scholar : PubMed/NCBI
7	Taylor JW, Flanagan EP, O'Neill BP, Siegal T, Omuro A, Deangelis L, Baehring J, Nishikawa R, Pinto F, Chamberlain M, et al: Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report. Neurology. 81:1690–1696. 2013. View Article : Google Scholar : PubMed/NCBI
8	Johnson BA, Fram EK, Johnson PC and Jacobowitz R: The variable MR appearance of primary lymphoma of the central nervous system: Comparison with histopathologic features. AJNR Am J Neuroradiol. 18:563–572. 1997.PubMed/NCBI
9	Levitt LJ, Dawson DM, Rosenthal DS and Moloney WC: CNS involvement in the non-Hodgkin's lymphomas. Cancer. 45:545–552. 1980. View Article : Google Scholar : PubMed/NCBI
10	Martin SE, Khalidi HS and Hattab EM: Marginal zone B-cell lymphoma involving a longstanding fibrous meningioma: An initial manifestation of systemic disease. Hum Pathol. 44:2609–2613. 2013. View Article : Google Scholar : PubMed/NCBI