Effects of hydration combined with Shenfu injection on contrast‑induced acute kidney injury in acute coronary syndrome patients undergoing percutaneous coronary intervention

  • Authors:
    • Zhen Guo
    • Dandan Niu
    • Yaren Yu
    • Di Zhen
    • Wenhua Li
  • View Affiliations

  • Published online on: September 22, 2017     https://doi.org/10.3892/br.2017.986
  • Pages: 477-481
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Abstract

The aim of the present study was to evaluate the efficacy and safety of the Shenfu injection (SFI) in the prevention of contrast‑induced acute kidney injury (CI‑AKI) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). A single‑center prospective and randomized controlled trial was performed and 148 ACS patients undergoing PCI were divided randomly into control (n=74; receiving only 0.9% sodium chloride solution for routine hydration) and intervention (n=74; based upon routine hydration and receiving SFI) groups. Serum creatinine (Scr), blood urea nitrogen and urinary neutrophil gelatinase‑associated lipocalin (NGAL) were evaluated at the start, and 1 and 2 days after PCI. Among the 148 patients, 14 (9.4%) experienced CI‑AKI subsequent to the procedure. CI‑AKI occurred in 2.7% of the SFI group and 16.2% of the control group (P<0.05). The incidence of CI‑AKI was lower in the intervention group when compared with the control. No serious adverse effects were observed in all patients. No differences between the levels of Scr and estimated glomerular filtration rate in the two groups were identified. However, 12 h after PCI, the urinary NGAL level in the control group was significantly higher than that in the SFI group (P<0.05). Thus, hydration combined with SFI was identified to be more effective than hydration with sodium chloride in the prevention of CI‑AKI in ACS patients undergoing PCI.
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November-2017
Volume 7 Issue 5

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Spandidos Publications style
Guo Z, Niu D, Yu Y, Zhen D and Li W: Effects of hydration combined with Shenfu injection on contrast‑induced acute kidney injury in acute coronary syndrome patients undergoing percutaneous coronary intervention. Biomed Rep 7: 477-481, 2017
APA
Guo, Z., Niu, D., Yu, Y., Zhen, D., & Li, W. (2017). Effects of hydration combined with Shenfu injection on contrast‑induced acute kidney injury in acute coronary syndrome patients undergoing percutaneous coronary intervention. Biomedical Reports, 7, 477-481. https://doi.org/10.3892/br.2017.986
MLA
Guo, Z., Niu, D., Yu, Y., Zhen, D., Li, W."Effects of hydration combined with Shenfu injection on contrast‑induced acute kidney injury in acute coronary syndrome patients undergoing percutaneous coronary intervention". Biomedical Reports 7.5 (2017): 477-481.
Chicago
Guo, Z., Niu, D., Yu, Y., Zhen, D., Li, W."Effects of hydration combined with Shenfu injection on contrast‑induced acute kidney injury in acute coronary syndrome patients undergoing percutaneous coronary intervention". Biomedical Reports 7, no. 5 (2017): 477-481. https://doi.org/10.3892/br.2017.986