Pattern of gynaecological malignancies in south western region of Pakistan: An overview of 12 years

Manzoor,Hina; Naheed,Hamida; Ahmad,Khushnaseeb; Iftikhar,Shehla; Asif,Muhammad; Shuja,Jamila; Sultan,Neelam; Ali,Irfan; Inayatullah,Syed; Khan,Yasir  Hayat

doi:10.3892/br.2017.993

Pattern of gynaecological malignancies in south western region of Pakistan: An overview of 12 years

Authors:
- Hina Manzoor
- Hamida Naheed
- Khushnaseeb Ahmad
- Shehla Iftikhar
- Muhammad Asif
- Jamila Shuja
- Neelam Sultan
- Irfan Ali
- Syed Inayatullah
- Yasir Hayat Khan
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Affiliations: Centre for Nuclear medicine and Radiotherapy (CENAR) Quetta 87300, Pakistan, Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta 87300, Pakistan, Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad 38000, Pakistan, Akhuwat-Faisalabad Institute of Research Science and Technology, Faisalabad 38000, Pakistan, School of Life Sciences, Xiamen University, Xiamen, Fujian 361000, P.R. China
Published online on: September 28, 2017 https://doi.org/10.3892/br.2017.993
Pages: 487-491

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Abstract

Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. The aim of this retrospective study was to determine the pattern of gynaecological malignancies identified between January, 2000 and December, 2011, at the Centre for Nuclear Medicine and Radiotherapy (CENAR). At CENAR 5,072 female patients were registered with different malignancies, of which 632 cases were gynaecological malignancies. Ovarian cancer (47%) was the most common gynaecological malignancy, followed by cervical cancer (29%), uterine cancer (14%), vulvar and vaginal cancer (6%), and gestational trophoblastic neoplasm (4%). Of the ovarian cancer cases, 72.5% had epithelial while 26.5% had non‑epithelial cancer. Squamous cell carcinoma was 75.9% in cervix and 87.8% in vulva and vagina while endometrial carcinoma (75.9%) was more frequent in uterus. For gestational trophoblastic neoplasm, 69.2% of patients had choriocarcinoma. Ovarian cancer was the most common type for the age range of 50-59 years. In the case of cervical and gestational trophoblastic neoplasm the majority of patients presented at the ages of 40-49 and 30-39 years while uterus, vulvar and vaginal tumor presented in the elderly (>60 years). Thus, ovarian cancer is the leading gynecological malignancy in Pakistan.

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