Qixiang Shao
Jiangsu University, China
- Orcid: 0000-0002-8332-1605
- Publications: N/A
- Citations: N/A
- Keywords: Thymus atrophy, Autoimmune disease, Ovarian cancer, Spesis.
Short Bio
- Prof. Qixiang Shao, M.D., Ph.D Education: Ph.D., Immunology, Peking University Health Science Center, China 2005 M.S., Immunology, Tongji Medical College of Huazhong University of Science and Technology, China 1999 M.D., NanJing Medical University, China 1987 Current Positions: Second Grade Professor of Immunology, Laboratory Diagnosis Direct of Institute of Medical Genetics and Reproductive Immunity, Jiangsu College of Nursing, Huai’an, Jiangsu, P. R. China. Dean of School of Medical Science and Laboratory Medicine, Jiangsu College of Nursing, Huai’an, Jiangsu, P. R. China. Current Academic Positions: 2004- Deputy Secretary-General of the Jiangsu Society for Immunology 2009- Deputy Secretary-General of Chinese Society for Immunology Transplantation Immunology Branch Contact Information: School of Medical Science and Laboratory Medicine, Jiangsu College of Nursing 9 Keji Avenue. Huai’an, Jiangsu 223002, P. R. China Phone 86-517-80823522 Email: shao_qx@ujs.edu.cn Research Description: I am interested in understanding cellular and molecular mechanisms the thymus atrophy and degeneration in transplantation, serious infection, chemistry and radiation therapy. We want to find or develop some drugs for protect the thymus involution and contribute to T cell reconstruction. The second major area of interest in T cell development, especially focus on the mechanism of non-coding RNA regulates T cell development and the balance impaired in the Th17/Tregs in autoimmune disease including the immune mechanism involved in recurrent spontaneous abortion (RSA). Knowledge gained from these studies has led us to develop effective gene therapy for autoimmune disease and transplantation. We have recently discovered that some LncRNA involve in the development of ovarian cancer via deep sequence analysis. We want to find the mechanism of these LncRNA promotes ovarian cancer. Selected Publications: 1. Liu X, Hartman CL, Li L, Albert CJ, Si F, Gao A, Huang L, Zhao Y, Lin W, Hsueh EC, Shen L, Shao Q, Hoft DF, Ford DA, Peng G※. Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy. Sci Transl Med. 2021;13(587):eaaz6314. 2. Zhao Y, Liu X, Si F, Huang L, Gao A, Lin W, Hoft DF, Shao Q※, Peng G※. Citrate Promotes Excessive Lipid Biosynthesis and Senescence in Tumor Cells for Tumor Therapy. Adv Sci (Weinh). 2022;9(1):e2101553. 3. Zhao Y, Shao Q, Peng G※. Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment. Cell Mol Immunol. 2020;17(1):27-35 4. Xie M, Wang J, Gong W, Xu H, Pan X, Chen Y, Ru S, Wang H, Chen X, Zhao Y, Li J, Yin Q, Xia S, Zhou X, Liu X※, Shao Q※. NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3. J Autoimmun. 2019;102:96-113. 5. Yan M, Yang X, Shen R, Wu C, Wang H, Ye Q, Yang P, Zhang L, Chen M, Wan B, Zhang Q, Xia S, Lu X, Shao G, Zhou X, Yu J, Shao Q※. miR-146b promotes cell proliferation and increases chemosensitivity, but attenuates cell migration and invasion via FBXL10 in ovarian cancer. Cell Death Dis. 2018;9(11):1123. 6. Wang J, Zhuo Y, Yin L, Wang H, Jiang Y, Liu X, Zhang M, Du F, Xia S, Shao Q※. Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-κB-Bcl-2/Bax Axis. Cell Physiol Biochem. 2016;38(2):449-60. 7. Yan L, Zhang H, Ma H, Liu D, Li W, Kang Y, Yang R, Wang J, He G, Xie X, Wang H, Wei L, Lu Z, Shao Q※, Chen H※. Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients. Sci Rep. 2015;5:17950. 8. Fan XY, Tian C, Wang H, Xu Y, Ren K, Zhang BY, Gao C, Shi Q, Meng G, Shao QX※, Dong XP※. Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection. Sci Rep. 2015;5:14728. 9. Wang H, Tian C, Fan XY, Chen LN, Lv Y, Sun J, Zhao YJ, Zhang LB, Wang J, Shi Q, Gao C, Chen C, Shao QX※, Dong XP※. Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrPSc in prion infected cell line via protein interaction. Int J Biochem Cell Biol. 2015;62:24-35 10. Liu X, Ji B, Sun M, Wu W, Huang L, Sun A, Zong Y, Xia S, Shi L, Qian H, Xu W, Shao Q※. Cell penetrable -mFoxp3 alleviates experimental arthritis in mice by up-regulating regulatory T cells. Clin Exp Immunol. 2015;181(1):87-99 11. Liu X, Zhao Q, Peng X, Xia S, Shen W, Zong Y, Cheng J, Wu W, Zhang M, Du F, Xu W, Qian H, Shao Q※. PTD-mediated intracellular delivery of mutant NFAT minimum DNA binding domain inhibited the proliferation of T cells. Int Immunopharmacol. 2014;19(1):110-8. 6. 12. Wang H, Tian C, Xu Y, Xie WL, Zhang J, Zhang BY, Ren K, Wang K, Chen C, Wang SB, Shi Q, Shao QX※, Dong XP※. Abortive cell cycle events in the brains of scrapie-infected hamsters with remarkable decreases of PLK3/Cdc25C and increases of PLK1/cyclin B1. Mol Neurobiol. 2013;48(3):655-68. 13. Guo X, Gao L, Liao Q, Xiao H, Ma X, Yang X, Luo H, Zhao G, Bu D, Jiao F, Shao Q, Chen R, Zhao Y. Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks. Nucleic Acids Res. 2013;41(2):e35. 14. Liu X, Xu X, Lin X, Tian Y, Ji B, Xia S, Xu S, Yin Q, Zhang M, Jiao Z, Wang S, Xu H, Shao Q※. PTD-hFOXP3 protein acts as an immune regulator to convert human CD4+CD25- T cells to regulatory T-like cells. J Cell Biochem. 2012;113(12):3797-809. 15. Huang Y, Li R, Chen X, Zhuo Y, Jin R, Qian XP, Jiang YQ, Zeng ZH, Zhang Y, Shao QX※. Doxycycline up-regulates the expression of IL-6 and GM-CSF via MAPK/ERK and NF-κB pathways in mouse thymic epithelial cells. Int Immunopharmacol. 2011;11(9):1143-9. 16. Chen X, Xia S, Li R, Liu H, Huang Y, Qian X, Xiao X, Xu X, Lin X, Tian Y, Zong Y, He D, Chen W, Zhang Y※, Shao Q※. Doxycycline enhances the Ras-MAPK signaling and proliferation of mouse thymic epithelial cells. J Cell Biochem. 2009;107(3):494-503. 17. Naik SH, Proietto AI, Wilson NS, Dakic A, Schnorrer P, Fuchsberger M, Lahoud MH, O'Keeffe M, Shao QX, Chen WF, Villadangos JA, Shortman K※, Wu L※. Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol. 2005;174(11):6592-7. 18. Dakic A, Shao QX, D'Amico A, O'Keeffe M, Chen WF, Shortman K※, Wu L※. Development of the dendritic cell system during mouse ontogeny. J Immunol. 2004;172(2):1018-27. ※ Corresponding author
