Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats

  • Authors:
    • Li Luo
    • Kaihua Guo
    • Wenguo Fan
    • Yinghong Lu
    • Lizhi Chen
    • Yang Wang
    • Yijia Shao
    • Gongxiong Wu
    • Jie Xu
    • Lanhai Lü
  • View Affiliations

  • Published online on: December 30, 2016     https://doi.org/10.3892/etm.2016.4016
  • Pages: 645-650
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Abstract

Niche astrocytes have been reported to promote neuronal differentiation through juxtacrine signaling. However, the effects of astrocytes on neuronal differentiation following ischemic stroke are not fully understood. In the present study, transplanted astrocytes and neural stem cells (NSCs) were transplanted into the ischemic striatum of transient middle cerebral artery occlusion (MCAO) model rats 48 h following surgery. It was observed that the co‑transplantation of astrocytes and NSCs resulted in a higher ratio of survival and proliferation of the transplanted NSCs, and neuronal differentiation, in MCAO rats compared with NSC transplantation alone. These results demonstrate that the co‑administration of astrocytes promotes the survival and neuronal differentiation of NSCs in the ischemic brain. These results suggest that the co‑transplantation of astrocytes and NSCs is more effective than NSCs alone in the production of neurons following ischemic stroke in rats.

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February-2017
Volume 13 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Luo L, Guo K, Fan W, Lu Y, Chen L, Wang Y, Shao Y, Wu G, Xu J, Lü L, Lü L, et al: Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats. Exp Ther Med 13: 645-650, 2017.
APA
Luo, L., Guo, K., Fan, W., Lu, Y., Chen, L., Wang, Y. ... Lü, L. (2017). Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats. Experimental and Therapeutic Medicine, 13, 645-650. https://doi.org/10.3892/etm.2016.4016
MLA
Luo, L., Guo, K., Fan, W., Lu, Y., Chen, L., Wang, Y., Shao, Y., Wu, G., Xu, J., Lü, L."Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats". Experimental and Therapeutic Medicine 13.2 (2017): 645-650.
Chicago
Luo, L., Guo, K., Fan, W., Lu, Y., Chen, L., Wang, Y., Shao, Y., Wu, G., Xu, J., Lü, L."Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats". Experimental and Therapeutic Medicine 13, no. 2 (2017): 645-650. https://doi.org/10.3892/etm.2016.4016