Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas

  • Authors:
    • Rin Yamaguchi
    • Seiya Momosaki
    • Guang Gao
    • Chu Chieh Hsia
    • Masamichi Kojiro
    • Charles Scudamore
    • Edward Tabor
  • View Affiliations

  • Published online on: December 1, 2004     https://doi.org/10.3892/ijmm.14.6.1097
  • Pages: 1097-1100
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Abstract

Studies have suggested that a truncated form of the hepatitis C virus (HCV) core protein can enter hepatocyte nuclei and might play a role in HCV-associated hepato-carcinogenesis. In the present study, the HCV core gene from hepatocellular carcinomas (HCC) and/or adjacent non-tumorous liver tissues from eight patients was amplified by nested RT-PCR and sequenced. Mutations in the HCV core gene that would encode a truncated core protein were found in 4 of the 8 patients. Since truncated core proteins have been shown to be capable of entry into the hepatocyte nucleus (unlike HCV itself, which is an exclusively cytoplasmic virus), the detection of mutated sequences encoding them in these four HCC patients suggests that these mutations may have played a role in the development of these HCCs.

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December 2004
Volume 14 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yamaguchi R, Momosaki S, Gao G, Hsia CC, Kojiro M, Scudamore C and Tabor E: Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas. Int J Mol Med 14: 1097-1100, 2004.
APA
Yamaguchi, R., Momosaki, S., Gao, G., Hsia, C.C., Kojiro, M., Scudamore, C., & Tabor, E. (2004). Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas. International Journal of Molecular Medicine, 14, 1097-1100. https://doi.org/10.3892/ijmm.14.6.1097
MLA
Yamaguchi, R., Momosaki, S., Gao, G., Hsia, C. C., Kojiro, M., Scudamore, C., Tabor, E."Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas". International Journal of Molecular Medicine 14.6 (2004): 1097-1100.
Chicago
Yamaguchi, R., Momosaki, S., Gao, G., Hsia, C. C., Kojiro, M., Scudamore, C., Tabor, E."Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas". International Journal of Molecular Medicine 14, no. 6 (2004): 1097-1100. https://doi.org/10.3892/ijmm.14.6.1097