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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2008 Volume 21 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells

  • Authors:
    • Kug Chan Kim
    • Hyun Jeong Jun
    • Jin Sik Kim
    • In Gyu Kim

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Biology, Nuclear Environmental Safety Research Center, Korea Atomic Energy Research Institute, Daejeon 305-353, Korea
  • Pages: 489-498
    |
    Published online on: April 1, 2008
       https://doi.org/10.3892/ijmm.21.4.489
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Abstract

We previously demonstrated that combined treatment with extracts of the medicinal mushroom Ganoderma lucidum and the herb Duchesnea chrysantha (GDE) significantly suppresses cell growth and selectively induces apoptosis in human leukemia HL-60 cells, but not in normal cells. GDE?s mechanism of action and its activity against HL-60 cells suggest that it could be suitable for the combined-modality treatment of hematological malignancies. In the present study, we examined whether treatment with a combination of GDE and ionizing radiation enhances the therapeutic effect. We demonstrated that, when used in combination with radiation at a clinically relevant dose of 2 Gy, GDE further suppressed cell proliferation and induced apoptosis as well as micronuclei formation in HL-60 cells, leading to increased cell death. Furthermore, GDE pretreatment not only reduced radiation-induced G2/M-phase arrest, but also induced G1-phase arrest. These events are associated with the inhibition of cyclin-dependent kinase 1 (CDK1) phosphorylation and the dephosphorylation of retinoblastoma protein (pRB). Collectively, these data show that combined treatment with GDE and radiation enhances radiation-induced apoptosis and overall cell death. These findings may be clinically relevant and suggest a novel therapeutic strategy for increasing the efficacy of radiotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Kim KC, Jun HJ, Kim JS and Kim IG: Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells. Int J Mol Med 21: 489-498, 2008.
APA
Kim, K.C., Jun, H.J., Kim, J.S., & Kim, I.G. (2008). Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells. International Journal of Molecular Medicine, 21, 489-498. https://doi.org/10.3892/ijmm.21.4.489
MLA
Kim, K. C., Jun, H. J., Kim, J. S., Kim, I. G."Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells". International Journal of Molecular Medicine 21.4 (2008): 489-498.
Chicago
Kim, K. C., Jun, H. J., Kim, J. S., Kim, I. G."Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells". International Journal of Molecular Medicine 21, no. 4 (2008): 489-498. https://doi.org/10.3892/ijmm.21.4.489
Copy and paste a formatted citation
x
Spandidos Publications style
Kim KC, Jun HJ, Kim JS and Kim IG: Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells. Int J Mol Med 21: 489-498, 2008.
APA
Kim, K.C., Jun, H.J., Kim, J.S., & Kim, I.G. (2008). Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells. International Journal of Molecular Medicine, 21, 489-498. https://doi.org/10.3892/ijmm.21.4.489
MLA
Kim, K. C., Jun, H. J., Kim, J. S., Kim, I. G."Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells". International Journal of Molecular Medicine 21.4 (2008): 489-498.
Chicago
Kim, K. C., Jun, H. J., Kim, J. S., Kim, I. G."Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells". International Journal of Molecular Medicine 21, no. 4 (2008): 489-498. https://doi.org/10.3892/ijmm.21.4.489
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