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Ursolic acid inhibits early lesions of diabetic nephropathy

  • Authors:
    • Yi Zhou
    • Jian-Shuang Li
    • Xin Zhang
    • Ya-Jun Wu
    • Kun Huang
    • Ling Zheng

  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/ijmm_00000500
  • Pages: 565-570
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The present study sought to investigate the effects of ursolic acid (UA) on the development of glomerular hypertrophy and type IV collagen accumulation, two early lesions associated with diabetic nephropathy (DN). By treating streptozotocin (STZ)-induced diabetic mice with low-dose UA (0.01% in food) for three months, the diabetes-induced glomerular hypertrophy and type IV collagen accumulation in the kidneys were found to be markedly ameliorated. Further studies identified that UA treatment suppressed diabetes-induced activations of STAT-3, ERK1/2 and JNK pathways, but not the diabetes-induced activation of the p38 pathway. Furthermore, diabetes-induced overexpression of iNOS in the renal cortex was also significantly suppressed by the treatment. UA may thus be considered as a potential therapeutic agent in treating DN.

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Journal Cover

October 2010
Volume 26 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Zhou Y, Li J, Zhang X, Wu Y, Huang K and Zheng L: Ursolic acid inhibits early lesions of diabetic nephropathy . Int J Mol Med 26: 565-570, 2010.
APA
Zhou, Y., Li, J., Zhang, X., Wu, Y., Huang, K., & Zheng, L. (2010). Ursolic acid inhibits early lesions of diabetic nephropathy . International Journal of Molecular Medicine, 26, 565-570. https://doi.org/10.3892/ijmm_00000500
MLA
Zhou, Y., Li, J., Zhang, X., Wu, Y., Huang, K., Zheng, L."Ursolic acid inhibits early lesions of diabetic nephropathy ". International Journal of Molecular Medicine 26.4 (2010): 565-570.
Chicago
Zhou, Y., Li, J., Zhang, X., Wu, Y., Huang, K., Zheng, L."Ursolic acid inhibits early lesions of diabetic nephropathy ". International Journal of Molecular Medicine 26, no. 4 (2010): 565-570. https://doi.org/10.3892/ijmm_00000500