1
|
Simonneau G, Gatzoulis MA, Adatia I,
Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Krishna Kumar
R, Landzberg M, Machado RF, et al: Updated clinical classification
of pulmonary hypertension. J Am Coll Cardiol. 62(Suppl 25):
D34–D41. 2013. View Article : Google Scholar : PubMed/NCBI
|
2
|
D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky
EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM,
Kernis JT, et al: Survival in patients with primary pulmonary
hypertension. Results from a national prospective registry. Ann
Intern Med. 115:343–349. 1991. View Article : Google Scholar : PubMed/NCBI
|
3
|
Humbert M, Sitbon O, Chaouat A, Bertocchi
M, Habib G, Gressin V, Yaïci A, Weitzenblum E, Cordier JF, Chabot
F, et al: Survival in patients with idiopathic, familial, and
anorexigen-associated pulmonary arterial hypertension in the modern
management era. Circulation. 122:156–163. 2010. View Article : Google Scholar : PubMed/NCBI
|
4
|
Shimoda LA and Semenza GL: HIF and the
lung: Role of hypoxia-inducible factors in pulmonary development
and disease. Am J Respir Crit Care Med. 183:152–156. 2011.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Stenmark KR, Fagan KA and Frid MG:
Hypoxia-induced pulmonary vascular remodeling: Cellular and
molecular mechanisms. Circ Res. 99:675–691. 2006. View Article : Google Scholar : PubMed/NCBI
|
6
|
Thompson K and Rabinovitch M: Exogenous
leukocyte and endogenous elastases can mediate mitogenic activity
in pulmonary artery smooth muscle cells by release of
extracellular-matrix bound basic fibroblast growth factor. J Cell
Physiol. 166:495–505. 1996. View Article : Google Scholar : PubMed/NCBI
|
7
|
Dewachter L, Adnot S, Fadel E, Humbert M,
Maitre B, Barlier-Mur AM, Simonneau G, Hamon M, Naeije R and
Eddahibi S: Angiopoietin/Tie2 pathway influences smooth muscle
hyperplasia in idiopathic pulmonary hypertension. Am J Respir Crit
Care Med. 174:1025–1033. 2006. View Article : Google Scholar : PubMed/NCBI
|
8
|
Jones PL, Cowan KN and Rabinovitch M:
Tenascin-C, proliferation and subendothelial fibronectin in
progressive pulmonary vascular disease. Am J Pathol. 150:1349–1360.
1997.PubMed/NCBI
|
9
|
Wang GL, Jiang BH, Rue EA and Semenza GL:
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS
heterodimer regulated by cellular O2 tension. Proc Natl
Acad Sci USA. 92:5510–5514. 1995. View Article : Google Scholar
|
10
|
Semenza GL: Targeting HIF-1 for cancer
therapy. Nat Rev Cancer. 3:721–732. 2003. View Article : Google Scholar : PubMed/NCBI
|
11
|
Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun
X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT and
Semenza GL: Impaired physiological responses to chronic hypoxia in
mice partially deficient for hypoxia-inducible factor 1alpha. J
Clin Invest. 103:691–696. 1999. View
Article : Google Scholar : PubMed/NCBI
|
12
|
Ball MK, Waypa GB, Mungai PT, Nielsen JM,
Czech L, Dudley VJ, Beussink L, Dettman RW, Berkelhamer SK,
Steinhorn RH, et al: Regulation of hypoxia-induced pulmonary
hypertension by vascular smooth muscle hypoxia-inducible factor-1α.
Am J Respir Crit Care Med. 189:314–324. 2014. View Article : Google Scholar :
|
13
|
Tuder RM, Chacon M, Alger L, Wang J,
Taraseviciene-Stewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M,
Semenza GL, et al: Expression of angiogenesis-related molecules in
plexiform lesions in severe pulmonary hypertension: Evidence for a
process of disordered angiogenesis. J Pathol. 195:367–374. 2001.
View Article : Google Scholar : PubMed/NCBI
|
14
|
Brusselmans K, Compernolle V, Tjwa M,
Wiesener MS, Maxwell PH, Collen D and Carmeliet P: Heterozygous
deficiency of hypoxia-inducible factor-2alpha protects mice against
pulmonary hypertension and right ventricular dysfunction during
prolonged hypoxia. J Clin Invest. 111:1519–1527. 2003. View Article : Google Scholar : PubMed/NCBI
|
15
|
Zhang R, Shi L, Zhou L, Zhang G, Wu X,
Shao F, Ma G and Ying K: Transgelin as a therapeutic target to
prevent hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol
Physiol. 306:L574–L583. 2014. View Article : Google Scholar : PubMed/NCBI
|
16
|
Wang L, Zhou Y, Li M and Zhu Y: Expression
of hypoxia-inducible factor-1α, endothelin-1 and adrenomedullin in
newborn rats with hypoxia-induced pulmonary hypertension. Exp Ther
Med. 8:335–339. 2014.PubMed/NCBI
|
17
|
Ko EA, Song MY, Donthamsetty R, Makino A
and Yuan JX: Tension measurement in isolated rat and mouse
pulmonary artery. Drug Discov Today Dis Models. 7:123–130. 2010.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Christou H, Morita T, Hsieh CM, Koike H,
Arkonac B, Perrella MA and Kourembanas S: Prevention of
hypoxia-induced pulmonary hypertension by enhancement of endogenous
heme oxygenase-1 in the rat. Circ Res. 86:1224–1229. 2000.
View Article : Google Scholar : PubMed/NCBI
|
19
|
Sreejayan N and Yang X: Isolation and
functional studies of rat aortic smooth muscle cells. Methods Mol
Med. 139:283–292. 2007. View Article : Google Scholar
|
20
|
Jones R, Zapol WM and Reid L: Pulmonary
artery remodeling and pulmonary hypertension after exposure to
hyperoxia for 7 days. A morphometric and hemodynamic study. Am J
Pathol. 117:273–285. 1984.PubMed/NCBI
|
21
|
Hänze J, Weissmann N, Grimminger F, Seeger
W and Rose F: Cellular and molecular mechanisms of
hypoxia-inducible factor driven vascular remodeling. Thromb
Haemost. 97:774–787. 2007.PubMed/NCBI
|
22
|
Fukai K, Nakamura A, Hoshino A, Nakanishi
N, Okawa Y, Ariyoshi M, Kaimoto S, Uchihashi M, Ono K, Tateishi S,
et al: Pyk2 aggravates hypoxia-induced pulmonary hypertension by
activating HIF-1α. Am J Physiol Heart Circ Physiol. 308:H951–H959.
2015. View Article : Google Scholar : PubMed/NCBI
|
23
|
Shan F, Li J and Huang QY: HIF-1
alpha-induced upregulation of miR-9 contributes to phenotypic
modulation in pulmonary artery smooth muscle cells during hypoxia.
J Cell Physiol. 229:1511–1520. 2014. View Article : Google Scholar : PubMed/NCBI
|
24
|
Chettimada S, Gupte R, Rawat D, Gebb SA,
McMurtry IF and Gupte SA: Hypoxia-induced glucose-6-phosphate
dehydrogenase overexpression and -activation in pulmonary artery
smooth muscle cells: Implication in pulmonary hypertension. Am J
Physiol Lung Cell Mol Physiol. 308:L287–L300. 2015. View Article : Google Scholar :
|
25
|
Fijalkowska I, Xu W, Comhair SA, Janocha
AJ, Mavrakis LA, Krishnamachary B, Zhen L, Mao T, Richter A,
Erzurum SC and Tuder RM: Hypoxia inducible-factor1alpha regulates
the metabolic shift of pulmonary hypertensive endothelial cells. Am
J Pathol. 176:1130–1138. 2010. View Article : Google Scholar : PubMed/NCBI
|
26
|
Maxwell PH, Wiesener MS, Chang GW,
Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER and
Ratcliffe PJ: The tumour suppressor protein VHL targets
hypoxia-inducible factors for oxygen-dependent proteolysis. Nature.
399:271–275. 1999. View
Article : Google Scholar : PubMed/NCBI
|
27
|
Fukuda R, Hirota K, Fan F, Jung YD, Ellis
LM and Semenza GL: Insulin-like growth factor 1 induces
hypoxia-inducible factor 1-mediated vascular endothelial growth
factor expression, which is dependent on MAP kinase and
phosphatidylinositol 3-kinase signaling in colon cancer cells. J
Biol Chem. 277:38205–38211. 2002. View Article : Google Scholar : PubMed/NCBI
|
28
|
Zhong H, Chiles K, Feldser D, Laughner E,
Hanrahan C, Georgescu MM, Simons JW and Semenza GL: Modulation of
hypoxia-inducible factor 1alpha expression by the epidermal growth
factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human
prostate cancer cells: Implications for tumor angiogenesis and
therapeutics. Cancer Res. 60:1541–1545. 2000.PubMed/NCBI
|
29
|
Alastalo TP, Li M, Perez VJ, Pham D,
Sawada H, Wang JK, Koskenvuo M, Wang L, Freeman BA, Chang HY and
Rabinovitch M: Disruption of PPARγ/β-catenin-mediated regulation of
apelin impairs BMP-induced mouse and human pulmonary arterial EC
survival. J Clin Invest. 121:3735–3746. 2011. View Article : Google Scholar : PubMed/NCBI
|
30
|
Schultz K, Fanburg BL and Beasley D:
Hypoxia and hypoxia-inducible factor-1alpha promote growth
factor-induced proliferation of human vascular smooth muscle cells.
Am J Physiol Heart Circ Physiol. 290:H2528–H2534. 2006. View Article : Google Scholar : PubMed/NCBI
|
31
|
Imanishi M, Tomita S, Ishizawa K, Kihira
Y, Ueno M, Izawa-Ishizawa Y, Ikeda Y, Yamano N, Tsuchiya K and
Tamaki T: Smooth muscle cell-specific Hif-1α deficiency suppresses
angiotensin II-induced vascular remodelling in mice. Cardiovasc
Res. 102:460–468. 2014. View Article : Google Scholar : PubMed/NCBI
|
32
|
Clayman GL, el-Naggar AK, Lippman SM,
Henderson YC, Frederick M, Merritt JA, Zumstein LA, Timmons TM, Liu
TJ, Ginsberg L, et al: Adenovirus-mediated p53 gene transfer in
patients with advanced recurrent head and neck squamous cell
carcinoma. J Clin Oncol. 16:2221–2232. 1998.PubMed/NCBI
|
33
|
Manno CS, Pierce GF, Arruda VR, Glader B,
Ragni M, Rasko JJ, Ozelo MC, Hoots K, Blatt P, Konkle B, et al:
Successful transduction of liver in hemophilia by AAV-Factor IX and
limitations imposed by the host immune response. Nat Med.
12:342–347. 2006. View
Article : Google Scholar : PubMed/NCBI
|
34
|
Kim SS, Garg H, Joshi A and Manjunath N:
Strategies for targeted nonviral delivery of siRNAs in vivo. Trends
Mol Med. 15:491–500. 2009. View Article : Google Scholar : PubMed/NCBI
|