Mitochondria-mediated damage to dopaminergic neurons in Parkinson's disease (Review)
- Authors:
- Xiao‑Liang Liu
- Ying‑Di Wang
- Xiu‑Ming Yu
- Da‑Wei Li
- Guang‑Ren Li
-
Affiliations: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 132021, P.R. China, Department of Urinary Surgery, The Tumor Hospital of Jilin Province, Changchun, Jilin 130012, P.R. China, Department of Immunology, The First Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R. China, Department of Neurology, Affiliated Hospital of Beihua University, Jilin, Jilin 132000, P.R. China, Department of Neurology, The Third Hospital of Jilin University, Changchun, Jilin 130021, P.R. China - Published online on: November 16, 2017 https://doi.org/10.3892/ijmm.2017.3255
- Pages: 615-623
This article is mentioned in:
Abstract
Forno LS: Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol. 55:259–272. 1996. View Article : Google Scholar : PubMed/NCBI | |
Martin LJ: Biology of mitochondria in neurodegenerative diseases. Prog Mol Biol Transl Sci. 107:355–415. 2012. View Article : Google Scholar : PubMed/NCBI | |
Trancikova A, Tsika E and Moore DJ: Mitochondrial dysfunction in genetic animal models of Parkinson's disease. Antioxid Redox Signal. 16:896–919. 2012. View Article : Google Scholar : | |
Ryan BJ, Hoek S, Fon EA and Wade-Martins R: Mitochondrial dysfunction and mitophagy in Parkinson's: From familial to sporadic disease. Trends Biochem Sci. 40:200–210. 2015. View Article : Google Scholar : PubMed/NCBI | |
Moon HE and Paek SH: Mitochondrial dysfunction in Parkinson's disease. Exp Neurobiol. 24:103–116. 2015. View Article : Google Scholar : PubMed/NCBI | |
Exner N, Lutz AK, Haass C and Winklhofer KF: Mitochondrial dysfunction in Parkinson's disease: Molecular mechanisms and pathophysiological consequences. EMBO J. 31:3038–3062. 2012. View Article : Google Scholar : PubMed/NCBI | |
Mounsey RB and Teismann P: Mitochondrial dysfunction in Parkinson's disease: Pathogenesis and neuroprotection. Parkinsons Dis. 2010:6174722011. | |
Martin LJ: Mitochondrial and cell death mechanisms in neurodegenerative diseases. Pharmaceuticals (Basel). 3:839–915. 2010. View Article : Google Scholar | |
Reddy PH and Reddy TP: Mitochondria as a therapeutic target for aging and neurodegenerative diseases. Curr Alzheimer Res. 8:393–409. 2011. View Article : Google Scholar : PubMed/NCBI | |
Reddy PH and Beal MF: Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Res Brain Res Rev. 49:618–632. 2005. View Article : Google Scholar : PubMed/NCBI | |
Rostovtseva TK, Tan W and Colombini M: On the role of VDAC in apoptosis: fact and fiction. J Bioenerg Biomembr. 37:129–142. 2005. View Article : Google Scholar : PubMed/NCBI | |
Okada SF, O'Neal WK, Huang P, Nicholas RA, Ostrowski LE, Craigen WJ, Lazarowski ER and Boucher RC: Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. J Gen Physiol. 124:513–526. 2004. View Article : Google Scholar : PubMed/NCBI | |
Camara AK, Lesnefsky EJ and Stowe DF: Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal. 13:279–347. 2010. View Article : Google Scholar : | |
Bernardi P: Mitochondrial transport of cations: Channels, exchangers, and permeability transition. Physiol Rev. 79:1127–1155. 1999. View Article : Google Scholar : PubMed/NCBI | |
Teshima Y, Akao M, Jones SP and Marbán E: Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res. 93:192–200. 2003. View Article : Google Scholar : PubMed/NCBI | |
O'Rourke B: Mitochondrial ion channels. Annu Rev Physiol. 69:19–49. 2007. View Article : Google Scholar | |
Wingrove DE and Gunter TE: Kinetics of mitochondrial calcium transport. II A kinetic description of the sodium-dependent calcium efflux mechanism of liver mitochondria and inhibition by ruthenium red and by tetraphenylphosphonium. J Biol Chem. 261:15166–15171. 1986.PubMed/NCBI | |
Bernardi P, Krauskopf A, Basso E, Petronilli V, Blachly-Dyson E, Di Lisa F and Forte MA: The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J. 273:2077–2099. 2006. View Article : Google Scholar : PubMed/NCBI | |
Leung AW and Halestrap AP: Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim Biophys Acta. 1777:946–952. 2008. View Article : Google Scholar : PubMed/NCBI | |
Vyssokikh MY, Katz A, Rueck A, Wuensch C, Dörner A, Zorov DB and Brdiczka D: Adenine nucleotide translocator isoforms 1 and 2 are differently distributed in the mitochondrial inner membrane and have distinct affinities to cyclophilin D. Biochem J. 358:349–358. 2001. View Article : Google Scholar : PubMed/NCBI | |
Halestrap AP and Brenner C: The adenine nucleotide translocase: A central component of the mitochondrial permeability transition pore and key player in cell death. Curr Med Chem. 10:1507–1525. 2003. View Article : Google Scholar : PubMed/NCBI | |
Ojala D, Montoya J and Attardi G: tRNA punctuation model of RNA processing in human mitochondria. Nature. 290:470–474. 1981. View Article : Google Scholar : PubMed/NCBI | |
Reddy PH: Amyloid precursor protein-mediated free radicals and oxidative damage: Implications for the development and progression of Alzheimer's disease. J Neurochem. 96:1–13. 2006. View Article : Google Scholar | |
Brookes PS, Levonen AL, Shiva S, Sarti P and Darley-Usmar VM: Mitochondria: Regulators of signal transduction by reactive oxygen and nitrogen species. Free Radic Biol Med. 33:755–764. 2002. View Article : Google Scholar : PubMed/NCBI | |
Dröge W: Free radicals in the physiological control of cell function. Physiol Rev. 82:47–95. 2002. View Article : Google Scholar : PubMed/NCBI | |
Kudin AP, Bimpong-Buta NY, Vielhaber S, Elger CE and Kunz WS: Characterization of superoxide-producing sites in isolated brain mitochondria. J Biol Chem. 279:4127–4135. 2004. View Article : Google Scholar | |
Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL and Parker N: Mitochondrial superoxide: Production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med. 37:755–767. 2004. View Article : Google Scholar : PubMed/NCBI | |
Andreyev AY, Kushnareva YE and Starkov AA: Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc). 70:200–214. 2005. View Article : Google Scholar | |
Cadenas E and Davies KJ: Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 29:222–230. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kudin AP, Debska-Vielhaber G and Kunz WS: Characterization of superoxide production sites in isolated rat brain and skeletal muscle mitochondria. Biomed Pharmacother. 59:163–168. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kussmaul L and Hirst J: The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci USA. 103:7607–7612. 2006. View Article : Google Scholar : PubMed/NCBI | |
Rush JD and Koppenol WH: Oxidizing intermediates in the reaction of ferrous EDTA with hydrogen peroxide. Reactions with organic molecules and ferrocytochrome c. J Biol Chem. 261:6730–6733. 1986.PubMed/NCBI | |
Antunes F, Han D and Cadenas E: Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions. Free Radic Biol Med. 33:1260–1267. 2002. View Article : Google Scholar : PubMed/NCBI | |
Morán M, Moreno-Lastres D, Marín-Buera L, Arenas J, Martín MA and Ugalde C: Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration. Free Radic Biol Med. 53:595–609. 2012. View Article : Google Scholar : PubMed/NCBI | |
Gutteridge JM: Superoxide-dependent formation of hydroxyl radicals from ferric-complexes and hydrogen peroxide: An evaluation of fourteen iron chelators. Free Radic Res Commun. 9:119–125. 1990. View Article : Google Scholar : PubMed/NCBI | |
Hwang O: Role of oxidative stress in Parkinson's disease. Exp Neurobiol. 22:11–17. 2013. View Article : Google Scholar : PubMed/NCBI | |
Dias V, Junn E and Mouradian MM: The role of oxidative stress in Parkinson's disease. J Parkinsons Dis. 3:461–491. 2013.PubMed/NCBI | |
Jenner P: Oxidative stress in Parkinson's disease. Ann Neurol. 53(Suppl 3): S26–S38. 2003. View Article : Google Scholar : PubMed/NCBI | |
Alam ZI, Jenner A, Daniel SE, Lees AJ, Cairns N, Marsden CD, Jenner P and Halliwell B: Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem. 69:1196–1203. 1997. View Article : Google Scholar : PubMed/NCBI | |
Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER and Mizuno Y: Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci USA. 93:2696–2701. 1996. View Article : Google Scholar : PubMed/NCBI | |
Li DW, Yao M, Dong YH, Tang MN, Chen W, Li GR and Sun BQ: Guanosine exerts neuroprotective effects by reversing mitochondrial dysfunction in a cellular model of Parkinson's disease. Int J Mol Med. 34:1358–1364. 2014. View Article : Google Scholar : PubMed/NCBI | |
Seet RC, Lee CY, Lim EC, Tan JJ, Quek AM, Chong WL, Looi WF, Huang SH, Wang H and Chan YH: Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. Free Radic Biol Med. 48:560–566. 2010. View Article : Google Scholar | |
Callio J, Oury TD and Chu CT: Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains. J Biol Chem. 280:18536–18542. 2005. View Article : Google Scholar : PubMed/NCBI | |
Vila M and Przedborski S: Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci. 4:365–375. 2003. View Article : Google Scholar : PubMed/NCBI | |
Perier C, Bové J, Vila M and Przedborski S: The rotenone model of Parkinson's disease. Trends Neurosci. 26:345–346. 2003. View Article : Google Scholar : PubMed/NCBI | |
Sun SY, An CN and Pu XP: DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats. Brain Res Bull. 88:609–616. 2012. View Article : Google Scholar : PubMed/NCBI | |
Heikkila RE, Hess A and Duvoisin RC: Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science. 224:1451–1453. 1984. View Article : Google Scholar : PubMed/NCBI | |
Barzilai A and Yamamoto K: DNA damage responses to oxidative stress. DNA Repair (Amst). 3:1109–1115. 2004. View Article : Google Scholar | |
Ruipérez V, Darios F and Davletov B: Alpha-synuclein, lipids and Parkinson's disease. Prog Lipid Res. 49:420–428. 2010. View Article : Google Scholar : PubMed/NCBI | |
Mariani E, Polidori MC, Cherubini A and Mecocci P: Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview. J Chromatogr B Analyt Technol Biomed Life Sci. 827:65–75. 2005. View Article : Google Scholar : PubMed/NCBI | |
Montine TJ, Neely MD, Quinn JF, Beal MF, Markesbery WR, Roberts LJ II and Morrow JD: Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med. 33:620–626. 2002. View Article : Google Scholar : PubMed/NCBI | |
Liu W, Kato M, Akhand AA, Hayakawa A, Suzuki H, Miyata T, Kurokawa K, Hotta Y, Ishikawa N and Nakashima I: 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. J Cell Sci. 113:635–641. 2000.PubMed/NCBI | |
Schmidt H, Grune T, Müller R, Siems WG and Wauer RR: Increased levels of lipid peroxidation products malondialdehyde and 4-hydroxynonenal after perinatal hypoxia. Pediatr Res. 40:15–20. 1996. View Article : Google Scholar : PubMed/NCBI | |
Montine KS, Quinn JF, Zhang J, Fessel JP, Roberts LJ II, Morrow JD and Montine TJ: Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem Phys Lipids. 128:117–124. 2004. View Article : Google Scholar : PubMed/NCBI | |
Lotharius J and Brundin P: Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci. 3:932–942. 2002. View Article : Google Scholar : PubMed/NCBI | |
Fornstedt B and Carlsson A: A marked rise in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following reserpine treatment. J Neural Transm. 76:155–161. 1989. View Article : Google Scholar : PubMed/NCBI | |
Youdim MB, Edmondson D and Tipton KF: The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci. 7:295–309. 2006. View Article : Google Scholar : PubMed/NCBI | |
Fowler JS, Volkow ND, Wang GJ, Logan J, Pappas N, Shea C and MacGregor R: Age-related increases in brain monoamine oxidase B in living healthy human subjects. Neurobiol Aging. 18:431–435. 1997. View Article : Google Scholar : PubMed/NCBI | |
Nagatsu T and Sawada M: Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: Possible implications of glial cells. J Neural Transm Suppl. 71:53–65. 2006. View Article : Google Scholar | |
Kumar MJ and Andersen JK: Perspectives on MAO-B in aging and neurological disease: Where do we go from here? Mol Neurobiol. 30:77–89. 2004. View Article : Google Scholar : PubMed/NCBI | |
Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H and Lee VM: Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J Biol Chem. 280:21212–21219. 2005. View Article : Google Scholar : PubMed/NCBI | |
Zecca L, Wilms H, Geick S, Claasen JH, Brandenburg LO, Holzknecht C, Panizza ML, Zucca FA, Deuschl G, Sievers J, et al: Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: Implications for Parkinson's disease. Acta Neuropathol. 116:47–55. 2008. View Article : Google Scholar : PubMed/NCBI | |
Jomova K and Valko M: Advances in metal-induced oxidative stress and human disease. Toxicology. 283:65–87. 2011. View Article : Google Scholar : PubMed/NCBI | |
Núñez MT, Urrutia P, Mena N, Aguirre P, Tapia V and Salazar J: Iron toxicity in neurodegeneration. Biometals. 25:761–776. 2012. View Article : Google Scholar : PubMed/NCBI | |
Sadrzadeh SM and Saffari Y: Iron and brain disorders. Am J Clin Pathol. 121(Suppl): S64–S70. 2004.PubMed/NCBI | |
Sian-Hülsmann J, Mandel S, Youdim MB and Riederer P: The relevance of iron in the pathogenesis of Parkinson's disease. J Neurochem. 118:939–957. 2011. View Article : Google Scholar | |
Sziráki I, Mohanakumar KP, Rauhala P, Kim HG, Yeh KJ and Chiueh CC: Manganese: A transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonism. Neuroscience. 85:1101–1111. 1998. View Article : Google Scholar : PubMed/NCBI | |
Lan J and Jiang DH: Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J Neural Transm Vienna. 104:469–481. 1997. View Article : Google Scholar : PubMed/NCBI | |
Faucheux BA, Martin ME, Beaumont C, Hauw JJ, Agid Y and Hirsch EC: Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease. J Neurochem. 86:1142–1148. 2003. View Article : Google Scholar : PubMed/NCBI | |
Yokoyama H, Kuroiwa H, Yano R and Araki T: Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease. Neurol Sci. 29:293–301. 2008. View Article : Google Scholar : PubMed/NCBI | |
Duchen MR: Mitochondria in health and disease: Perspectives on a new mitochondrial biology. Mol Aspects Med. 25:365–451. 2004. View Article : Google Scholar : PubMed/NCBI | |
Henchcliffe C and Beal MF: Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol. 4:600–609. 2008. View Article : Google Scholar : PubMed/NCBI | |
Mythri RB, Jagatha B, Pradhan N, Andersen J and Bharath MM: Mitochondrial complex I inhibition in Parkinson's disease: How can curcumin protect mitochondria? Antioxid Redox Signal. 9:399–408. 2007. View Article : Google Scholar | |
Adams JM and Cory S: The Bcl-2 protein family: Arbiters of cell survival. Science. 281:1322–1326. 1998. View Article : Google Scholar : PubMed/NCBI | |
Crompton M: The mitochondrial permeability transition pore and its role in cell death. Biochem J. 341:233–249. 1999. View Article : Google Scholar : PubMed/NCBI | |
Burchell VS, Gandhi S, Deas E, Wood NW, Abramov AY and Plun-Favreau H: Targeting mitochondrial dysfunction in neurodegenerative disease: Part I. Expert Opin Ther Targets. 14:369–385. 2010. View Article : Google Scholar : PubMed/NCBI | |
Moon Y, Lee KH, Park JH, Geum D and Kim K: Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: Protective effect of coenzyme Q10. J Neurochem. 93:1199–1208. 2005. View Article : Google Scholar : PubMed/NCBI | |
McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H and Pandey S: Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10. Toxicol Appl Pharmacol. 201:21–31. 2004. View Article : Google Scholar : PubMed/NCBI | |
Cleren C, Yang L, Lorenzo B, Calingasan NY, Schomer A, Sireci A, Wille EJ and Beal MF: Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism. J Neurochem. 104:1613–1621. 2008. View Article : Google Scholar | |
Dubois C, Prevarskaya N and Vanden Abeele F: The calcium-signaling toolkit: Updates needed. Biochim Biophys Acta. 1863:1337–1343. 2016. View Article : Google Scholar | |
Santo-Domingo J, Wiederkehr A and De Marchi U: Modulation of the matrix redox signaling by mitochondrial Ca(2). World J Biol Chem. 6:310–323. 2015. View Article : Google Scholar : PubMed/NCBI | |
Nicholls DG: Mitochondrial function and dysfunction in the cell: Its relevance to aging and aging-related disease. Int J Biochem Cell Biol. 34:1372–1381. 2002. View Article : Google Scholar : PubMed/NCBI | |
Kirichok Y, Krapivinsky G and Clapham DE: The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 427:360–364. 2004. View Article : Google Scholar : PubMed/NCBI | |
Gincel D, Zaid H and Shoshan-Barmatz V: Calcium binding and translocation by the voltage-dependent anion channel: A possible regulatory mechanism in mitochondrial function. Biochem J. 358:147–155. 2001. View Article : Google Scholar : PubMed/NCBI | |
Takeuchi A, Kim B and Matsuoka S: The destiny of Ca(2+) released by mitochondria. J Physiol Sci. 65:11–24. 2015. View Article : Google Scholar | |
Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, et al: MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One. 8:e557852013. View Article : Google Scholar : PubMed/NCBI | |
Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE and Mootha VK: MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature. 467:291–296. 2010. View Article : Google Scholar : PubMed/NCBI | |
McCormack JG and Denton RM: Mitochondrial Ca2+ transport and the role of intramitochondrial Ca2+ in the regulation of energy metabolism. Dev Neurosci. 15:165–173. 1993. View Article : Google Scholar | |
Balaban RS: Cardiac energy metabolism homeostasis: Role of cytosolic calcium. J Mol Cell Cardiol. 34:1259–1271. 2002. View Article : Google Scholar : PubMed/NCBI | |
Alderton WK, Cooper CE and Knowles RG: Nitric oxide synthases: Structure, function and inhibition. Biochem J. 357:593–615. 2001. View Article : Google Scholar : PubMed/NCBI | |
Jekabsone A, Ivanoviene L, Brown GC and Borutaite V: Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release. J Mol Cell Cardiol. 35:803–809. 2003. View Article : Google Scholar : PubMed/NCBI | |
Brookes PS, Yoon Y, Robotham JL, Anders MW and Sheu SS: Calcium, ATP, and ROS: A mitochondrial love-hate triangle. Am J Physiol Cell Physiol. 287:C817–C833. 2004. View Article : Google Scholar : PubMed/NCBI | |
Muravchick S and Levy RJ: Clinical implications of mitochondrial dysfunction. Anesthesiology. 105:819–837. 2006. View Article : Google Scholar : PubMed/NCBI | |
O'Rourke B: Pathophysiological and protective roles of mitochondrial ion channels. J Physiol. 529:23–36. 2000. View Article : Google Scholar : PubMed/NCBI | |
Di Lisa F and Bernardi P: A CaPful of mechanisms regulating the mitochondrial permeability transition. J Mol Cell Cardiol. 46:775–780. 2009. View Article : Google Scholar : PubMed/NCBI | |
Jones SP, Teshima Y, Akao M and Marbán E: Simvastatin attenuates oxidant-induced mitochondrial dysfunction in cardiac myocytes. Circ Res. 93:697–699. 2003. View Article : Google Scholar : PubMed/NCBI | |
Celardo I, Martins LM and Gandhi S: Unravelling mitochondrial pathways to Parkinson's disease. Br J Pharmacol. 171:1943–1957. 2014. View Article : Google Scholar : | |
Surmeier DJ, Guzman JN, Sanchez-Padilla J and Goldberg JA: The origins of oxidant stress in Parkinson's disease and therapeutic strategies. Antioxid Redox Signal. 14:1289–1301. 2011. View Article : Google Scholar : | |
Perier C, Tieu K, Guégan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S and Vila M: Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci USA. 102:19126–19131. 2005. View Article : Google Scholar : PubMed/NCBI | |
Boatright KM and Salvesen GS: Mechanisms of caspase activation. Curr Opin Cell Biol. 15:725–731. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kumar S: Caspase function in programmed cell death. Cell Death Differ. 14:32–43. 2007. View Article : Google Scholar | |
Javadov S, Choi A, Rajapurohitam V, Zeidan A, Basnakian AG and Karmazyn M: NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition. Cardiovasc Res. 77:416–424. 2008. View Article : Google Scholar | |
Wallace DC: A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine. Annu Rev Genet. 39:359–407. 2005. View Article : Google Scholar : PubMed/NCBI | |
Yang JL, Weissman L, Bohr VA and Mattson MP: Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst). 7:1110–1120. 2008. View Article : Google Scholar | |
Levy RJ and Deutschman CS: Deficient mitochondrial biogenesis in critical illness: Cause, effect, or epiphenomenon? Crit Care. 11:1582007. View Article : Google Scholar : PubMed/NCBI | |
Elstner M, Müller SK, Leidolt L, Laub C, Krieg L, Schlaudraff F, Liss B, Morris C, Turnbull DM, Masliah E, et al: Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions. Mol Brain. 4:432011. View Article : Google Scholar : PubMed/NCBI | |
Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW and Khrapko K: Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet. 38:518–520. 2006. View Article : Google Scholar : PubMed/NCBI | |
Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, et al: High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet. 38:515–517. 2006. View Article : Google Scholar : PubMed/NCBI | |
Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, et al: Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci USA. 104:1325–1330. 2007. View Article : Google Scholar : PubMed/NCBI | |
Tanner CM, Kamel F, Ross GW, Hoppin JA, Goldman SM, Korell M, Marras C, Bhudhikanok GS, Kasten M, Chade AR, et al: Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect. 119:866–872. 2011. View Article : Google Scholar : PubMed/NCBI | |
Halliwell B: Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment. Drugs Aging. 18:685–716. 2001. View Article : Google Scholar : PubMed/NCBI | |
Reeve AK, Krishnan KJ and Turnbull D: Mitochondrial DNA mutations in disease, aging, and neurodegeneration. Ann NY Acad Sci. 1147:21–29. 2008. View Article : Google Scholar : PubMed/NCBI | |
Ropp PA and Copeland WC: Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma. Genomics. 36:449–458. 1996. View Article : Google Scholar : PubMed/NCBI | |
Luoma P, Melberg A, Rinne JO, Kaukonen JA, Nupponen NN, Chalmers RM, Oldfors A, Rautakorpi I, Peltonen L, Majamaa K, et al: Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: Clinical and molecular genetic study. Lancet. 364:875–882. 2004. View Article : Google Scholar : PubMed/NCBI | |
Wong LJ, Naviaux RK, Brunetti-Pierri N, Zhang Q, Schmitt ES, Truong C, Milone M, Cohen BH, Wical B, Ganesh J, et al: Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Hum Mutat. 29:E150–E172. 2008. View Article : Google Scholar : PubMed/NCBI | |
Gui YX, Xu ZP, Lv W, Zhao JJ and Hu XY: Evidence for polymerase gamma, POLG1 variation in reduced mitochondrial DNA copy number in Parkinson's disease. Parkinsonism Relat Disord. 21:282–286. 2015. View Article : Google Scholar : PubMed/NCBI | |
Hudson G and Chinnery PF: Mitochondrial DNA polymerase-gamma and human disease. Hum Mol Genet. 15:R244–R252. 2006. View Article : Google Scholar : PubMed/NCBI | |
Sanders LH, McCoy J, Hu X, Mastroberardino PG, Dickinson BC, Chang CJ, Chu CT, Van Houten B and Greenamyre JT: Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease. Neurobiol Dis. 70:214–223. 2014. View Article : Google Scholar : PubMed/NCBI | |
Wilson DM III and Barsky D: The major human abasic endonuclease: Formation, consequences and repair of abasic lesions in DNA. Mutat Res. 485:283–307. 2001. View Article : Google Scholar : PubMed/NCBI | |
Benard G and Karbowski M: Mitochondrial fusion and division: Regulation and role in cell viability. Semin Cell Dev Biol. 20:365–374. 2009. View Article : Google Scholar : PubMed/NCBI | |
Soubannier V and McBride HM: Positioning mitochondrial plasticity within cellular signaling cascades. Biochim Biophys Acta. 1793:154–170. 2009. View Article : Google Scholar | |
Schrader M: Shared components of mitochondrial and peroxisomal division. Biochim Biophys Acta. 1763:531–541. 2006. View Article : Google Scholar : PubMed/NCBI | |
Ishihara N, Jofuku A, Eura Y and Mihara K: Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells. Biochem Biophys Res Commun. 301:891–898. 2003. View Article : Google Scholar : PubMed/NCBI | |
Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P and Scorrano L: Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA. 105:15803–15808. 2008. View Article : Google Scholar : PubMed/NCBI | |
Han XJ, Lu YF, Li SA, Kaitsuka T, Sato Y, Tomizawa K, Nairn AC, Takei K, Matsui H and Matsushita M: CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol. 182:573–585. 2008. View Article : Google Scholar : PubMed/NCBI | |
Reddy PH, Reddy TP, Manczak M, Calkins MJ, Shirendeb U and Mao P: Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res Brain Res Rev. 67:103–118. 2011. View Article : Google Scholar | |
James DI, Parone PA, Mattenberger Y and Martinou JC: hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem. 278:36373–36379. 2003. View Article : Google Scholar : PubMed/NCBI | |
Gomes LC and Scorrano L: High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta. 1777:860–866. 2008. View Article : Google Scholar : PubMed/NCBI | |
Santos D and Cardoso SM: Mitochondrial dynamics and neuronal fate in Parkinson's disease. Mitochondrion. 12:428–437. 2012. View Article : Google Scholar : PubMed/NCBI | |
Reddy PH: Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease. Exp Neurol. 218:286–292. 2009. View Article : Google Scholar : PubMed/NCBI | |
Reddy PH: Mitochondrial dysfunction in aging and Alzheimer's disease: Strategies to protect neurons. Antioxid Redox Signal. 9:1647–1658. 2007. View Article : Google Scholar : PubMed/NCBI | |
Chen H, Chomyn A and Chan DC: Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem. 280:26185–26192. 2005. View Article : Google Scholar : PubMed/NCBI | |
Ishihara N, Eura Y and Mihara K: Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J Cell Sci. 117:6535–6546. 2004. View Article : Google Scholar : PubMed/NCBI | |
Züchner S, Mersiyanova IV, Muglia M, Bissar-Tadmouri N, Rochelle J, Dadali EL, Zappia M, Nelis E, Patitucci A, Senderek J, et al: Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet. 36:449–451. 2004. View Article : Google Scholar : PubMed/NCBI | |
Armstrong JS: Mitochondria-directed therapeutics. Antioxid Redox Signal. 10:575–578. 2008. View Article : Google Scholar | |
Chan DC: Mitochondria: Dynamic organelles in disease, aging, and development. Cell. 125:1241–1252. 2006. View Article : Google Scholar : PubMed/NCBI | |
McBride HM, Neuspiel M and Wasiak S: Mitochondria: More than just a powerhouse. Curr Biol. 16:R551–R560. 2006. View Article : Google Scholar : PubMed/NCBI | |
Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, et al: Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 25:3900–3911. 2006. View Article : Google Scholar : PubMed/NCBI | |
Head B, Griparic L, Amiri M, Gandre-Babbe S and van der Bliek AM: Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. J Cell Biol. 187:959–966. 2009. View Article : Google Scholar : PubMed/NCBI | |
Abou-Sleiman PM, Muqit MM and Wood NW: Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci. 7:207–219. 2006. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang JW, Yang L, Beal MF, Vogel H and Lu B: Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci USA. 103:10793–10798. 2006. View Article : Google Scholar : PubMed/NCBI | |
Park J, Lee SB, Lee S, Kim Y, Song S, Kim S, Bae E, Kim J, Shong M, Kim JM and Chung J: Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature. 441:1157–1161. 2006. View Article : Google Scholar : PubMed/NCBI | |
Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP and Youle RJ: Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol. 191:933–942. 2010. View Article : Google Scholar : PubMed/NCBI | |
Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR and Youle RJ: PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 8:e10002982010. View Article : Google Scholar : PubMed/NCBI | |
Kim Y, Park J, Kim S, Song S, Kwon SK, Lee SH, Kitada T, Kim JM and Chung J: PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun. 377:975–980. 2008. View Article : Google Scholar : PubMed/NCBI | |
Sha D, Chin LS and Li L: Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet. 19:352–363. 2010. View Article : Google Scholar | |
Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ and Springer W: PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol. 12:119–131. 2010. View Article : Google Scholar : PubMed/NCBI |