Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model.

  • Authors:
    • K Yoshidome
    • M A Shibata
    • I G Maroulakou
    • M L Liu
    • C L Jorcyk
    • L G Gold
    • V N Welch
    • J E Green
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijo.12.2.449
  • Pages: 449-502
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Abstract

We have generated a transgenic mouse model in which female mice develop ductal mammary adenocarcinomas and male mice develop prostatic adenocarcinomas by using a transgene containing the hormone-responsive rat prostatic steroid binding protein 5' flanking region C3(1) fused to the simian virus 40 (SV40) large T antigen. We have identified some genetic alterations during mammary and prostate tumor progression: (i) p53 is functionally inactivated during mammary cancer development without p53 mutations; (ii) Alterations in apoptosis during mammary tumor progression are p53 and bcl-2 independent; (iii) Ha-ras mutations occur early in the development of prostate cancer. This unique animal model offers the opportunity to study multistep tumorigenesis in these organs.

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Feb 1998
Volume 12 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yoshidome K, Shibata M, Maroulakou I, Liu M, Jorcyk C, Gold L, Welch V and Green J: Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model.. Int J Oncol 12: 449-502, 1998.
APA
Yoshidome, K., Shibata, M., Maroulakou, I., Liu, M., Jorcyk, C., Gold, L. ... Green, J. (1998). Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model.. International Journal of Oncology, 12, 449-502. https://doi.org/10.3892/ijo.12.2.449
MLA
Yoshidome, K., Shibata, M., Maroulakou, I., Liu, M., Jorcyk, C., Gold, L., Welch, V., Green, J."Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model.". International Journal of Oncology 12.2 (1998): 449-502.
Chicago
Yoshidome, K., Shibata, M., Maroulakou, I., Liu, M., Jorcyk, C., Gold, L., Welch, V., Green, J."Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model.". International Journal of Oncology 12, no. 2 (1998): 449-502. https://doi.org/10.3892/ijo.12.2.449