Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review)

  • Authors:
    • Gerd J. Bauerschmitz
    • Shannon D. Barker
    • Akseli Hemminki
  • View Affiliations

  • Published online on: December 1, 2002     https://doi.org/10.3892/ijo.21.6.1161
  • Pages: 1161-1174
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Abstract

Gene therapy is an exciting novel approach for treating cancers resistant to currently available modalities. Treatment approaches are based on taking advantage of molecular differences between normal and tumor cells. Various strategies are currently in clinical development, with some promising early results reported with mutation compensation, molecular chemotherapy and replication competent viruses. Adenoviruses are among the most popular vehicles and there is a wealth of clinical data suggesting excellent safety for treatment of cancer patients. Current developments include improving targeting strategies for gene delivery to tumor cells with tumor specific promoters. Another rapidly developing field is replication competent agents, which allow improved tumor penetration and local amplification of the anti-tumor effect. Further, infectivity enhancement strategies can overcome variable expression of the primary adenovirus receptor on tumor cells, which may have reduced the clinical efficacy of previous strategies. Adenoviral cancer gene therapy approaches lack cross-resistance with other treatment options and frequently synergistic effects can be observed. Therefore, the first routine clinical applications are likely to be combination treatments.

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December 2002
Volume 21 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Bauerschmitz GJ, Barker SD and Hemminki A: Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review). Int J Oncol 21: 1161-1174, 2002.
APA
Bauerschmitz, G.J., Barker, S.D., & Hemminki, A. (2002). Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review). International Journal of Oncology, 21, 1161-1174. https://doi.org/10.3892/ijo.21.6.1161
MLA
Bauerschmitz, G. J., Barker, S. D., Hemminki, A."Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review)". International Journal of Oncology 21.6 (2002): 1161-1174.
Chicago
Bauerschmitz, G. J., Barker, S. D., Hemminki, A."Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review)". International Journal of Oncology 21, no. 6 (2002): 1161-1174. https://doi.org/10.3892/ijo.21.6.1161