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Synthesis and in vitro investigation of cationic 5,15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers

  • Authors:
    • Nela Malatesti
    • Karen Smith
    • Huguette Savoie
    • John Greenman
    • Ross W. Boyle

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  • Published online on: June 1, 2006     https://doi.org/10.3892/ijo.28.6.1561
  • Pages: 1561-1569
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Abstract

The synthesis of three cationic 5,15-diphenyl porphyrins, bearing an isothiocyanate group for conjugation to proteins is described. The potential of these compounds as targeted photosensitisers for use in photodynamic therapy (PDT) is demonstrated by their efficient conjugation to monoclonal antibodies and the ability of the bioconjugates to bind and photodynamically inactivate cancer cells that express the corresponding antigen.

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June 2006
Volume 28 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Malatesti N, Smith K, Savoie H, Greenman J and Boyle RW: Synthesis and in vitro investigation of cationic 5,15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers. Int J Oncol 28: 1561-1569, 2006.
APA
Malatesti, N., Smith, K., Savoie, H., Greenman, J., & Boyle, R.W. (2006). Synthesis and in vitro investigation of cationic 5,15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers. International Journal of Oncology, 28, 1561-1569. https://doi.org/10.3892/ijo.28.6.1561
MLA
Malatesti, N., Smith, K., Savoie, H., Greenman, J., Boyle, R. W."Synthesis and in vitro investigation of cationic 5,15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers". International Journal of Oncology 28.6 (2006): 1561-1569.
Chicago
Malatesti, N., Smith, K., Savoie, H., Greenman, J., Boyle, R. W."Synthesis and in vitro investigation of cationic 5,15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers". International Journal of Oncology 28, no. 6 (2006): 1561-1569. https://doi.org/10.3892/ijo.28.6.1561