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Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

  • Authors:
    • Ido Wolf
    • James O'Kelly
    • Naoki Wakimoto
    • Anh Nguyen
    • Franck Amblard
    • Beth Y. Karlan
    • Jack L. Arbiser
    • H. Phillip Koeffler

  • View Affiliations

  • Published online on: June 1, 2007     https://doi.org/10.3892/ijo.30.6.1529
  • Pages: 1529-1537
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Abstract

Honokiol (HNK), a naturally occurring biphenyl, possesses potent antineoplastic and antiangiogenic properties. We investigated the in vitro and in vivo activity of HNK against breast cancer. HNK exhibited potent anti-proliferative activity against breast cancer cell lines and enhanced the activity of other drugs used for the treatment of breast cancer. In vivo, HNK was highly effective against breast cancer in nude mice. We identified two different effects of HNK on breast cancer cells: cell cycle inhibition, observed at lower doses of HNK, and induction of apoptosis, observed at higher doses of the compound. Our data suggest that HNK is a systemically available, non-toxic inhibitor of breast cancer growth and should be examined for clinical applications.

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Journal Cover

June 2007
Volume 30 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Wolf I, O'Kelly J, Wakimoto N, Nguyen A, Amblard F, Karlan BY, Arbiser JL and Koeffler HP: Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. Int J Oncol 30: 1529-1537, 2007.
APA
Wolf, I., O'Kelly, J., Wakimoto, N., Nguyen, A., Amblard, F., Karlan, B.Y. ... Koeffler, H.P. (2007). Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. International Journal of Oncology, 30, 1529-1537. https://doi.org/10.3892/ijo.30.6.1529
MLA
Wolf, I., O'Kelly, J., Wakimoto, N., Nguyen, A., Amblard, F., Karlan, B. Y., Arbiser, J. L., Koeffler, H. P."Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest". International Journal of Oncology 30.6 (2007): 1529-1537.
Chicago
Wolf, I., O'Kelly, J., Wakimoto, N., Nguyen, A., Amblard, F., Karlan, B. Y., Arbiser, J. L., Koeffler, H. P."Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest". International Journal of Oncology 30, no. 6 (2007): 1529-1537. https://doi.org/10.3892/ijo.30.6.1529