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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2011 Volume 39 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2011 Volume 39 Issue 6

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Article

Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor

  • Authors:
    • Roberto Carrio
    • Marta Torroella-Kouri
    • Stephania Libreros
    • Ramón A. García-Areas
    • Vijaya Iragavarapu-Charyulu
    • Diana M. López

  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA, Department of Basic Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USA
  • Pages: 1619-1627
    |
    Published online on: August 18, 2011
       https://doi.org/10.3892/ijo.2011.1169
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Abstract

During mammary tumorigenesis, there is a profound tumor-induced immunosuppression and a progressive thymic atrophy associated with tumor development. IFN-γ has been shown to be effective in enhancing antitumor responses in several tumor models, however, how IFN-γ exerts its anti-tumor effect is largely controversial. In the present study we have used a mammary tumor model to investigate whether the levels of IFN-γ have an important role in the tumor-induced immuno-suppression as well as in the pathogenesis of the thymic atrophy. We evaluated this possibility using DA-3 cells transfected to express IFN-γ (DA-3/IFN-γ), a system that provides constant, local production of IFN-γ within the tumor microenvironment. Overexpression of IFN-γ in the mammary tumor results in a marked delay of tumor growth, a reduction in regulatory T cells and myeloid-derived suppressor cells accumulation mostly due to down-regulation of chemokines implicated in the recruitment of immune regulatory cells, and a blockage in the tumor-associated thymus atrophy. Collectively, our data suggest that the replacement of the faulty levels of IFN-γ in the tumor results in a diminution of the tumor-induced immune suppression caused by the mammary tumor development.

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Copy and paste a formatted citation
Spandidos Publications style
Carrio R, Torroella-Kouri M, Libreros S, García-Areas RA, Iragavarapu-Charyulu V and López DM: Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor. Int J Oncol 39: 1619-1627, 2011.
APA
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R.A., Iragavarapu-Charyulu, V., & López, D.M. (2011). Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor. International Journal of Oncology, 39, 1619-1627. https://doi.org/10.3892/ijo.2011.1169
MLA
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R. A., Iragavarapu-Charyulu, V., López, D. M."Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor". International Journal of Oncology 39.6 (2011): 1619-1627.
Chicago
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R. A., Iragavarapu-Charyulu, V., López, D. M."Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor". International Journal of Oncology 39, no. 6 (2011): 1619-1627. https://doi.org/10.3892/ijo.2011.1169
Copy and paste a formatted citation
x
Spandidos Publications style
Carrio R, Torroella-Kouri M, Libreros S, García-Areas RA, Iragavarapu-Charyulu V and López DM: Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor. Int J Oncol 39: 1619-1627, 2011.
APA
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R.A., Iragavarapu-Charyulu, V., & López, D.M. (2011). Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor. International Journal of Oncology, 39, 1619-1627. https://doi.org/10.3892/ijo.2011.1169
MLA
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R. A., Iragavarapu-Charyulu, V., López, D. M."Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor". International Journal of Oncology 39.6 (2011): 1619-1627.
Chicago
Carrio, R., Torroella-Kouri, M., Libreros, S., García-Areas, R. A., Iragavarapu-Charyulu, V., López, D. M."Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor". International Journal of Oncology 39, no. 6 (2011): 1619-1627. https://doi.org/10.3892/ijo.2011.1169
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