Open Access

miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway

  • Authors:
    • Manman Xu
    • Juan Xiao
    • Ming Chen
    • Linjing Yuan
    • Jundong Li
    • Hongwei Shen
    • Shuzhong Yao
  • View Affiliations

  • Published online on: January 24, 2018     https://doi.org/10.3892/ijo.2018.4252
  • Pages: 815-827
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chemotherapeutic resistance remains a critical clinical issue is responsible for treatment failure in patients with ovarian cancer. Evidence of the involvement of miRNAs in chemoresistance in ovarian cancer has been recently emerging. However, the underlying molecular links between chemoresistance and miRNAs remain largely unknown. In this study, we report that miR‑149‑5p expression is markedly elevated in chemoresistant ovarian cancer tissues compared with the chemosensitive ovarian cancer tissues. Furthermore, the silencing of miR‑149‑5p enhanced the chemosensitivity of ovarian cancer cells to cisplatin in vitro and in vivo. Conversely, the upregulation of miR‑149‑5p aggravated chemoresistance in ovarian cancer cells. Our results further revealed that miR‑149‑5p directly targeted the core kinase components of the Hippo signaling pathway, STE20-like kinase (MST)1 and protein salvador homolog 1 (SAV1), resulting in the inactivation of TEA domain (TEAD) transcription. On the whole, our findings reveal a novel mechanism of of action miR‑149‑5p in inducing chemotherapeutic resistance in ovarian cancer, indicating that miR‑149‑5p may serve as a chemotherapeutic response indicator and a potential therapeutic target in ovarian cancer.
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March-2018
Volume 52 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Xu M, Xiao J, Chen M, Yuan L, Li J, Shen H and Yao S: miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. Int J Oncol 52: 815-827, 2018
APA
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., & Yao, S. (2018). miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. International Journal of Oncology, 52, 815-827. https://doi.org/10.3892/ijo.2018.4252
MLA
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., Yao, S."miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway". International Journal of Oncology 52.3 (2018): 815-827.
Chicago
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., Yao, S."miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway". International Journal of Oncology 52, no. 3 (2018): 815-827. https://doi.org/10.3892/ijo.2018.4252