search button

PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA

  • Authors:
    • HR NAIK
    • D PETRYLAK
    • A YAGODA
    • JE LEHR
    • A AKHTAR
    • KJ PIENTA

  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.209
  • Pages: 209-213
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vive, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.

Related Articles

Journal Cover

January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
NAIK H, PETRYLAK D, YAGODA A, LEHR J, AKHTAR A and PIENTA K: PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA. Int J Oncol 6: 209-213, 1995.
APA
NAIK, H., PETRYLAK, D., YAGODA, A., LEHR, J., AKHTAR, A., & PIENTA, K. (1995). PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA. International Journal of Oncology, 6, 209-213. https://doi.org/10.3892/ijo.6.1.209
MLA
NAIK, H., PETRYLAK, D., YAGODA, A., LEHR, J., AKHTAR, A., PIENTA, K."PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA". International Journal of Oncology 6.1 (1995): 209-213.
Chicago
NAIK, H., PETRYLAK, D., YAGODA, A., LEHR, J., AKHTAR, A., PIENTA, K."PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA". International Journal of Oncology 6, no. 1 (1995): 209-213. https://doi.org/10.3892/ijo.6.1.209