Clinical value of serum tumor markers CA19‑9, CA125 and CA72-4 in the diagnosis of pancreatic carcinoma

Wang,Zi; Tian,Ya‑Ping

doi:10.3892/mco.2013.226

March-April 2014 Volume 2 Issue 2

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March-April 2014 Volume 2 Issue 2

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Article

Clinical value of serum tumor markers CA19‑9, CA125 and CA72-4 in the diagnosis of pancreatic carcinoma

Authors:
- Zi Wang
- Ya‑Ping Tian
View Affiliations / Copyright

Affiliations: Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing 100853, P.R. China
Pages: 265-268
|
Published online on: December 12, 2013

https://doi.org/10.3892/mco.2013.226
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Abstract

CA125 and CA72-4 are members of a family of high‑molecular weight glycosylated proteins and are commonly considered as biomarkers in the diagnosis of ovarian and gastric cancer, respectively. However, recent studies have revealed that these two markers may be of clinical value in the diagnosis of pancreatic cancer. As the availability of data regarding CA72-4 and CA125 in the diagnosis of pancreatic cancer is limited, the aim of this study was to investigate the clinical value of serum tumor markers CA19‑9, CA125 and CA72-4 in the diagnosis of pancreatic carcinoma according to logistic regression analysis and receiver operating characteristic (ROC) curves and to investigate the correlation of these markers with tumor TNM stage and location. An immunoradiometric assay was used to measure pre‑operative serum CA19‑9, CA125 and CA72-4 levels in 75 patients with pancreatic carcinoma and 70 patients with benign pancreatic diseases. The concentrations of serum CA19‑9, CA125 and CA72-4 in patients with pancreatic carcinoma were found to be significantly higher (P<0.05) compared with those with benign pancreatic diseases. The combined detection of two serum markers (CA19‑9 + CA72-4) yielded a ROC value of 0.895 that was significantly higher compared to others (P<0.05) in distinguishing pancreatic cancer from benign pancreatic diseases. At optimal cut‑off, the sensitivity and specificity of combined detection (CA19‑9 + CA72-4) were 70.6 and 92.8%, respectively. The concentrations of CA125 and CA19‑9 in patients with pancreatic adenocarcinoma were found to be significantly higher (P<0.05) compared with those of pancreatic neuroendocrine carcinoma. In conclusion, the combined detection of CA19‑9 and CA72-4) may significantly improve the diagnostic specificity and the serum concentrations of CA125 and CA19‑9 are correlated with tumor histological type.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical value of serum tumor markers CA19‑9, CA125 and CA72-4 in the diagnosis of pancreatic carcinoma

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