Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma

Shiiba,Masashi; Unozawa,Motoharu; Higo,Morihiro; Kouzu,Yukinao; Kasamatsu,Atsushi; Sakamoto,Yosuke; Ogawara,Katsunori; Uzawa,Katsuhiro; Takiguchi,Yuichi; Tanzawa,Hideki

doi:10.3892/mco.2014.291

Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma

Authors:
- Masashi Shiiba
- Motoharu Unozawa
- Morihiro Higo
- Yukinao Kouzu
- Atsushi Kasamatsu
- Yosuke Sakamoto
- Katsunori Ogawara
- Katsuhiro Uzawa
- Yuichi Takiguchi
- Hideki Tanzawa
View Affiliations

Affiliations: Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan, Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan
Published online on: May 8, 2014 https://doi.org/10.3892/mco.2014.291
Pages: 609-617

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The objective of this study was to elucidate the clinical characteristics of uncommon head and neck malignancies, such as non‑squamous cell carcinoma (SCC), in order to improve patient outcomes. A total of 463 head and neck malignancies were retrospectively analyzed, with 43 cases (9.3%) diagnosed as non‑SCC. The overall survival rate of patients with adenoid cystic carcinoma was significantly worse compared to that of patients with SCC. The 5‑year survival rates were <50% for patients with malignant melanoma, adenocarcinoma, small‑cell carcinoma and sarcomas. Distant metastasis to the lung was frequently observed in cases with a poor outcome. non‑SCC malignancies treated without surgery were associated with a worse outcome. Some non‑SCC patients had a poor prognosis and distant metastasis was associated with an unsatisfactory outcome. Timely treatment and control of distant metastasis are essential and surgical treatment should be prioritized in non‑SCC cases to improve patient outcomes.

View Figures

View References

1	Slootweg PJ and Eveson JW: Tumours of the oral cavity and oropharynx. World Health Organization Classification of Tumours (Pathology and Genetics of Head and Neck Tumours). Barnes L, Eveson JW, Reichart P and Sidransky D: IARC Press; Lyon: pp. 163–165. 2005
2	Krolls SO and Hoffman S: Squamous cell carcinoma of the oral soft tissues: a statistical analysis of 14,253 cases by age, sex, and race of patients. J Am Dent Assoc. 92:571–574. 1976. View Article : Google Scholar : PubMed/NCBI
3	Funk GF, Karnell LH, Robinson RA, Zhen WK, Trask DK and Hoffman HT: Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. Head Neck. 24:165–180. 2002. View Article : Google Scholar : PubMed/NCBI
4	Kemp S, Gallagher G, Kabani S, Noonan V and O’Hara C: Oral non-Hodgkin’s lymphoma: review of the literature and World Health Organization classification with reference to 40 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 105:194–201. 2008.
5	Al-Sukhun J, Lindqvist C, Hietanen J, Leivo I and Penttilä H: Central adenoid cystic carcinoma of the mandible: case report and literature review of 16 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:304–308. 2006. View Article : Google Scholar : PubMed/NCBI
6	Khan AJ, DiGiovanna MP, Ross DA, et al: Adenoid cystic carcinoma: a retrospective clinical review. Int J Cancer. 96:149–158. 2001. View Article : Google Scholar : PubMed/NCBI
7	Parashar P, Baron E, Papadimitriou JC, Ord RA and Nikitakis NG: Basal cell adenocarcinoma of the oral minor salivary glands: review of the literature and presentation of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 103:77–84. 2007. View Article : Google Scholar : PubMed/NCBI
8	do Prado RF, Lima CF, Pontes HA, Almeida JD, Cabral LA and Carvalho YR: Calcifications in a clear cell mucoepidermoid carcinoma: a case report with histological and immunohistochemical findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104:e40–e44. 2007.PubMed/NCBI
9	Corcione L, Giordano G, Gnetti L, Multinu A and Ferrari S: Oncocytic mucoepidermoid carcinoma of a submandibular gland: a case report and review of the literature. Int J Oral Maxillofac Surg. 36:560–563. 2007. View Article : Google Scholar : PubMed/NCBI
10	Sciubba JJ: Oral cancer. The importance of early diagnosis and treatment. Am J Clin Dermatol. 2:239–251. 2001.
11	Terada T: Small cell carcinoma of the oral cavity (cheek mucosa): a case report with an immunohistochemical and molecular genetic analysis. Int J Clin Exp Pathol. 6:780–787. 2013.PubMed/NCBI
12	Shenoy N, Sholapurkar AA, Pai KM and Pal K: Small cell carcinoma of the oral cavity: report of a rare case. J Calif Dent Assoc. 37:399–401. 2009.PubMed/NCBI
13	Shen C, Xu T, Huang C, Hu C and He S: Treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neck. Oral Oncol. 48:445–449. 2012. View Article : Google Scholar : PubMed/NCBI
14	Lin YC, Chen KC, Lin CH, Kuo KT, Ko JY and Hong RL: Clinicopathological features of salivary and non-salivary adenoid cystic carcinomas. Int J Oral Maxillofac Surg. 41:354–360. 2012. View Article : Google Scholar : PubMed/NCBI
15	Schmitt C, Sako N, Bagot M, Huang Y, Gaulard P and Bensussan A: Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targets. J Biomed Biotechnol. 2011:7908712011. View Article : Google Scholar : PubMed/NCBI
16	Coha B, Vucinic I, Mahovne I and Vukovic-Arar Z: Extranodal lymphomas of head and neck with emphasis on NK/T-cell lymphoma, nasal type. J Craniomaxillofac Surg. 42:149–152. 2014. View Article : Google Scholar : PubMed/NCBI
17	Miller TP, Dahlberg S, Cassady JR, et al: Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin’s lymphoma. N Engl J Med. 339:21–26. 1998.PubMed/NCBI
18	Yamaguchi M, Tobinai K, Oguchi M, et al: Concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: an updated analysis of the Japan clinical oncology group study JCOG0211. J Clin Oncol. 30:4044–4046. 2012. View Article : Google Scholar : PubMed/NCBI
19	Miloglu O, Altas SS, Buyukkurt MC, Erdemci B and Altun O: Rhabdomyosarcoma of the oral cavity: a case report. Eur J Dent. 5:340–343. 2011.PubMed/NCBI
20	Yamaguchi S, Nagasawa H, Suzuki T, et al: Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25 years. Clin Oral Investig. 8:52–55. 2004.PubMed/NCBI