Clinicopathological characteristics of infiltrating lobular breast carcinoma in elderly women: Preliminary results

Ruibal,Alvaro; Aguiar,Pablo; del Río,Maria  del Carmen; Menéndez,Primitiva; Arias,José  Ignacio; Herranz,Michel

doi:10.3892/mco.2015.625

Clinicopathological characteristics of infiltrating lobular breast carcinoma in elderly women: Preliminary results

Authors:
- Alvaro Ruibal
- Pablo Aguiar
- Maria del Carmen del Río
- Primitiva Menéndez
- José Ignacio Arias
- Michel Herranz
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Affiliations: Department of Radiology and Physical Medicine, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galicia 15706, Spain, Clinical Laboratory, Hospital Arquitecto Marcide/Novoa Santos, Ferrol, 15405 Galicia, Spain, Department of Pathology, Central University Hospital of Asturias, Oviedo, 33006 Asturias, Spain, Department of Surgery, Hospital Monte Naranco, Oviedo, 33012 Asturias, Spain, Department of Nuclear Medicine, University Hospital of Santiago de Compostela, Santiago de Compostela, 15706 Galicia, Spain
Published online on: August 28, 2015 https://doi.org/10.3892/mco.2015.625
Pages: 1337-1340

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Abstract

This study was conducted to investigate the clinicopathological parameters in elderly women (aged >70 years) with infiltrating lobular carcinoma (ILC) of the breast and compare the results with those obtained from younger patients (aged 55‑70 years). The study sample included a total of 46 women with ILCs, 10 aged >70 and 36 aged 55‑70 years. The parameters analysed were tumor size, histological grade (HG), axillary lymph node involvement, distant metastasis and immunohistochemical expression of estrogen, progesterone and androgen receptors, Ki67, p53 and B cell lymphoma 2. Compared to women aged 55‑70 years, ILCs in women aged >70 years were commonly of larger size (P=0.068) and were more frequently HG3 (P=0.024). There were no statistically significant differences in the other parameters analysed. Furthermore, we were unable to determine differences in cancer recurrence and mortality in the two patient subgroups during our follow‑up. In conclusion, our preliminary results, based on the limited number of cases included in this study, indicate that i) ILCs in women aged >70 years tended to be larger compared to those in women aged 55‑70 years and were more frequently of grade 3; and ii) there were no significant differences in terms of recurrence and mortality between the two patient subgroups during our follow-up.

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