In vivo detection of desmoplastic reaction using endocytoscopy: A new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma

Sugihara,Yuusaku; Kudo,Shin‑Ei; Miyachi,Hideyuki; Wakamura,Kunihiko; Mori,Yuichi; Misawa,Masashi; Hisayuki,Tomokazu; Kudo,Toyoki; Hayashi,Takemasa; Hamatani,Shigeharu; Okoshi,Shogo; Okada,Hiroyuki

doi:10.3892/mco.2017.1138

In vivo detection of desmoplastic reaction using endocytoscopy: A new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma

Authors:
- Yuusaku Sugihara
- Shin‑Ei Kudo
- Hideyuki Miyachi
- Kunihiko Wakamura
- Yuichi Mori
- Masashi Misawa
- Tomokazu Hisayuki
- Toyoki Kudo
- Takemasa Hayashi
- Shigeharu Hamatani
- Shogo Okoshi
- Hiroyuki Okada
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Affiliations: Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224‑0032, Japan, Department of Pathology, The Jikei University School of Medicine, Tokyo 105‑8461, Japan, Department of Internal Medicine, School of Life Dentistry at Niigata, The Nippon Dental University, Niigata 951‑1500, Japan, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan
Published online on: January 23, 2017 https://doi.org/10.3892/mco.2017.1138
Pages: 291-295
Copyright: © Sugihara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The pathological determination of desmoplastic reaction (DR) in colorectal carcinoma is useful for predicting extensive submucosal invasion. The aim of the present study was to determine the usefulness of endocytoscopy (EC) in detecting DR. A total of 72 cases of colorectal cancer with submucosal invasion (EC classification, EC3b) were evaluated. The utility of fine granular structure (FGS) observed via EC for the prediction of the presence of DR in the most superficial tumor layers was assessed. Of the 72 lesions, 26 were positive for FGS, and the majority of these lesions (23/26, 88.5%) exhibited a DR, indicating a significant association. The overall accuracy of the identification of FGS via EC that was predictive of a DR was 87.3%. The presence of FGS detected by EC was significantly associated with the presence of a DR, suggesting the clinical usefulness of EC in planning treatment for colon cancer with submucosal invasion.

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