A case of metastatic Xp11.2 translocation renal cell carcinoma successfully managed by cytoreductive nephrectomy followed by axitinib therapy

  • Authors:
    • Koichi Nishimura
    • Toshio Takagi
    • Naohiro Toda
    • Tomoko Yamamoto
    • Tsunenori Kondo
    • Hideki Ishida
    • Yoji Nagashima
    • Kazunari Tanabe
  • View Affiliations

  • Published online on: January 31, 2017     https://doi.org/10.3892/mco.2017.1142
  • Pages: 362-364
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Abstract

Targeted medications for metastatic adult Xp11.2 translocation renal cell carcinoma (RCC) remain to be identified. We herein report a case of metastatic Xp11.2 translocation RCC controlled with cytoreductive nephrectomy (CN) and axitinib therapy. A 57-year-old woman complained of fatigue and low back pain. Imaging studies revealed a right renal tumor, with multiple lung and mediastinal lymph node metastases. Although the patient received 10 mg axitinib therapy for 5 months at the hospital she was initially admitted to, the size of the primary and metastatic lesions was not reduced. Thus, she was referred to the Tokyo Women's Medical University Hospital (Tokyo, Japan) for further treatment, where she underwent CN. On macroscopic examination, almost the entire kidney was replaced by a yellowish brown tumor >80 mm in diameter. Immunohistochemical examination confirmed the diagnosis of Xp11.2 translocation RCC. One month after surgery, axitinib therapy was resumed and the size of the metastatic lesions gradually decreased. These findings suggest that axitinib therapy is effective for adult Xp11.2 translocation RCC.
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March-2017
Volume 6 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Nishimura K, Takagi T, Toda N, Yamamoto T, Kondo T, Ishida H, Nagashima Y and Tanabe K: A case of metastatic Xp11.2 translocation renal cell carcinoma successfully managed by cytoreductive nephrectomy followed by axitinib therapy. Mol Clin Oncol 6: 362-364, 2017
APA
Nishimura, K., Takagi, T., Toda, N., Yamamoto, T., Kondo, T., Ishida, H. ... Tanabe, K. (2017). A case of metastatic Xp11.2 translocation renal cell carcinoma successfully managed by cytoreductive nephrectomy followed by axitinib therapy. Molecular and Clinical Oncology, 6, 362-364. https://doi.org/10.3892/mco.2017.1142
MLA
Nishimura, K., Takagi, T., Toda, N., Yamamoto, T., Kondo, T., Ishida, H., Nagashima, Y., Tanabe, K."A case of metastatic Xp11.2 translocation renal cell carcinoma successfully managed by cytoreductive nephrectomy followed by axitinib therapy". Molecular and Clinical Oncology 6.3 (2017): 362-364.
Chicago
Nishimura, K., Takagi, T., Toda, N., Yamamoto, T., Kondo, T., Ishida, H., Nagashima, Y., Tanabe, K."A case of metastatic Xp11.2 translocation renal cell carcinoma successfully managed by cytoreductive nephrectomy followed by axitinib therapy". Molecular and Clinical Oncology 6, no. 3 (2017): 362-364. https://doi.org/10.3892/mco.2017.1142