Sudden cardiac death in a patient with advanced hepatocellular carcinoma with good response to sorafenib treatment: A case report with literature analysis

  • Authors:
    • Linda Calistri
    • Cesare Cordopatri
    • Cosimo Nardi
    • Elena Gianni
    • Fabio Marra
    • Stefano Colagrande
  • View Affiliations

  • Published online on: January 16, 2017     https://doi.org/10.3892/mco.2017.1132
  • Pages: 389-396
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Abstract

Hepatocellular carcinoma (HCC) is the principal primary liver tumor, representing the third largest cause of cancer‑associated death worldwide. The actual reference standard systemic treatment for advanced HCC is represented by sorafenib, a multi‑targeted orally active small‑molecule tyrosine kinase inhibitor. Sorafenib has exhibited a good general safety profile in multiple clinical trials. However, adverse drug‑associated events are common, occasionally severe, and special attention should be paid to cardiovascular adverse events, particularly in patients with risk factors or known heart disease. In the present study, the case of a patient with no known cardiovascular risk factors affected by highly enhancing advanced HCC in cirrhotic liver, who died during successful sorafenib monotherapy, is reported.
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March-2017
Volume 6 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Calistri L, Cordopatri C, Nardi C, Gianni E, Marra F and Colagrande S: Sudden cardiac death in a patient with advanced hepatocellular carcinoma with good response to sorafenib treatment: A case report with literature analysis. Mol Clin Oncol 6: 389-396, 2017
APA
Calistri, L., Cordopatri, C., Nardi, C., Gianni, E., Marra, F., & Colagrande, S. (2017). Sudden cardiac death in a patient with advanced hepatocellular carcinoma with good response to sorafenib treatment: A case report with literature analysis. Molecular and Clinical Oncology, 6, 389-396. https://doi.org/10.3892/mco.2017.1132
MLA
Calistri, L., Cordopatri, C., Nardi, C., Gianni, E., Marra, F., Colagrande, S."Sudden cardiac death in a patient with advanced hepatocellular carcinoma with good response to sorafenib treatment: A case report with literature analysis". Molecular and Clinical Oncology 6.3 (2017): 389-396.
Chicago
Calistri, L., Cordopatri, C., Nardi, C., Gianni, E., Marra, F., Colagrande, S."Sudden cardiac death in a patient with advanced hepatocellular carcinoma with good response to sorafenib treatment: A case report with literature analysis". Molecular and Clinical Oncology 6, no. 3 (2017): 389-396. https://doi.org/10.3892/mco.2017.1132