Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study

Maruyama,Takayuki; Tomofuji,Takaaki; Machida,Tatsuya; Kato,Hironari; Tsutsumi,Koichiro; Uchida,Daisuke; Takaki,Akinobu; Yoneda,Toshiki; Miyai,Hisataka; Mizuno,Hirofumi; Ekuni,Daisuke; Okada,Hiroyuki; Morita,Manabu

doi:10.3892/mco.2017.1220

Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study

Authors:
- Takayuki Maruyama
- Takaaki Tomofuji
- Tatsuya Machida
- Hironari Kato
- Koichiro Tsutsumi
- Daisuke Uchida
- Akinobu Takaki
- Toshiki Yoneda
- Hisataka Miyai
- Hirofumi Mizuno
- Daisuke Ekuni
- Hiroyuki Okada
- Manabu Morita
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Affiliations: Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama 700‑8558, Japan, Department of Community Oral Health, Asahi University School of Dentistry, Mizuho, Gifu 501‑0296, Japan, Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan
Published online on: April 10, 2017 https://doi.org/10.3892/mco.2017.1220
Pages: 683-687
Copyright: © Maruyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated. The Kaplan‑Meier method and Cox proportional hazards model were used to assess factors affecting the prognosis of pancreatobiliary tract cancer. The Kaplan-Meier analysis demonstrated that low body mass index, high concentration of serum C‑reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. The Cox proportional hazards model revealed that serum carbohydrate antigen 19‑9 concentration [hazard ratio (HR)=1.002; 95% confidence interval (CI): 1.000‑1.004] and serum CRP concentration (HR=2.57; 95% CI: 1.15‑5.74) were significantly associated with the prognosis of pancreatobiliary tract cancer. In addition, cancer patients with severe periodontitis had higher serum CRP concentrations compared with those without severe periodontitis. Therefore, severe periodontitis indirectly affected the prognosis of pancreatobiliary tract cancer through promoting systemic inflammation.

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