Morphological changes in peri-prostatic sympathetic ganglion cells in aging males

Rath‑Wolfson,Lea; Shvero,Asaf; Bubis,Golan; Buzaverov,Galina; Zeidman,Aliza; Ram,Edward; Koren,Rumelia

doi:10.3892/mco.2017.1196

Morphological changes in peri-prostatic sympathetic ganglion cells in aging males

Authors:
- Lea Rath‑Wolfson
- Asaf Shvero
- Golan Bubis
- Galina Buzaverov
- Aliza Zeidman
- Edward Ram
- Rumelia Koren
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Affiliations: Department of Pathology, Hasharon Hospital, Rabin Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Tel Aviv 6997801, Israel, Department of Urology, Sheba Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Tel Aviv 6997801, Israel, St. George's University of London, University of Nicosia Medical School, 2408 Nicosia, Cyprus, Department of Internal Medicine ‘B’, Hasharon Hospital, Rabin Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Tel Aviv 6997801, Israel, Department of Surgery ‘A’, Hasharon Hospital, Rabin Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Tel Aviv 6997801, Israel
Published online on: March 16, 2017 https://doi.org/10.3892/mco.2017.1196
Pages: 713-717

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Abstract

A significant part of morbidity in elderly male patients involves the pelvic organs and their autonomic neural regulation. The aim of the current study was to report the histopathological changes in the peri‑prostatic ganglia in elderly males. The sympathetic ganglia from 36 prostatectomy specimens, 26 due to carcinoma of the prostate and 10 prostates from total cystectomies for transitional cell carcinoma, were examined. The age range was 54‑88 years. A total of 5,075 ganglion cells were counted in all the specimens. Pathological changes were identified in 1,696 neuron cells as follows: Neuronophagia in 746 neuron cells, neuron cell vacuolization (330 cells), satellite cells vacuolization (423 cells), cell pyknosis (148 cells) and nageotte nodules (49 cells). A number of these changes increased with age. All the changes were more marked in the peri‑prostatic ganglion cells of patients with prostatic adenocarcinoma compared with those with benign prostate hyperplasia, which may be due to local environmental changes associated with the presence of malignancy.

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