Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta‑analysis

  • Authors:
    • Aikeremujiang Muheremu
    • Junyi Ma
    • Aierken Amudong
    • Yong Ma
    • Maimaitiaili Niyazi
    • Yong Ou
    • Yuan Ma
  • View Affiliations

  • Published online on: July 18, 2017     https://doi.org/10.3892/mco.2017.1329
  • Pages: 461-467
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In order to elucidate the value of positron emission tomography (PET)/computed tomography (CT) in the clinical diagnosis and treatment of osseous and soft tissue malignancies, two authors independently searched the PubMed, Medline, Elsevier, Embase and Cochrane Library databases for literature published between January 2003 and February 2016, using the key words ‘PET/CT’, ‘positron emission tomography/computed tomography’, ‘osseous sarcoma’, ‘bone tumor’, ‘soft tissue sarcoma’ and ‘neoadjuvant’, to identify prospective and retrospective studies on the applicability of PET/CT on the clinical diagnosis of bone and soft tissue lesions, and evaluation of their response to neoadjuvant therapies. Data were independently extracted by the two authors and any disagreements were resolved by a third author when necessary. Extracted data were analyzed by Meta‑Disc 1.6 software. As a result, 16 trials with a total of 883 patients and 2,214 lesions were included in the present study. The overall diagnostic accuracy of PET/CT exhibited a sensitivity and specificity of 0.90 (0.86‑0.92) and 0.89 (0.85‑0.92), respectively, and the effect of neoadjuvant therapy was assessed with a sensitivity and specificity of 0.79 (0.30‑0.93) and 0.79 (0.69‑0.89), respectively. Thus, it may be concluded from the present study that PET/CT is a reliable imaging method to be applied in the diagnosis and treatment of osseous and soft tissue malignancies.
View Figures
View References

Related Articles

Journal Cover

September-2017
Volume 7 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Muheremu A, Ma J, Amudong A, Ma Y, Niyazi M, Ou Y and Ma Y: Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta‑analysis. Mol Clin Oncol 7: 461-467, 2017
APA
Muheremu, A., Ma, J., Amudong, A., Ma, Y., Niyazi, M., Ou, Y., & Ma, Y. (2017). Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta‑analysis. Molecular and Clinical Oncology, 7, 461-467. https://doi.org/10.3892/mco.2017.1329
MLA
Muheremu, A., Ma, J., Amudong, A., Ma, Y., Niyazi, M., Ou, Y., Ma, Y."Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta‑analysis". Molecular and Clinical Oncology 7.3 (2017): 461-467.
Chicago
Muheremu, A., Ma, J., Amudong, A., Ma, Y., Niyazi, M., Ou, Y., Ma, Y."Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta‑analysis". Molecular and Clinical Oncology 7, no. 3 (2017): 461-467. https://doi.org/10.3892/mco.2017.1329