Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report

Xie,Linna; Zhou,Fang

doi:10.3892/mco.2017.1414

Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report

Authors:
- Linna Xie
- Fang Zhou
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Affiliations: Department of Hematology, The General Hospital of Jinan Military District, Jinan, Shandong 250031, P.R. China
Published online on: September 19, 2017 https://doi.org/10.3892/mco.2017.1414
Pages: 851-854

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Abstract

Post‑transplantation lymphoproliferative disease (PTLD) is a serious complication following hematopoietic stem cell transplantation (HSCT). The majority of the cases develop during the first year after the transplantation and are associated with reactivation of the Epstein‑Barr virus (EBV); the EBV‑induced lymphoproliferation usually includes donor‑derived B cells. We herein describe the case of a 28‑year‑old female patient who developed EBV‑negative PTLD, namely diffuse large B‑cell lymphoma (DLBCL), 6 months after receiving a haploidentical HSCT from her father. Chimerism analysis performed with XY fluorescence in situ hybridization revealed a B‑cell PTLD originating from the donor. Unfortunately, the donor also developed DLBCL 380 days after donating progenitor cells, although he was hematologically normal at the time of donation. The present case demonstrated that disease transmitted from the donor may be a possible cause of PTLD.

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