A strategy for the clinical remission of acute lymphoblastic leukemia elicited by treatment of β‑thalassemia major: A case report

Palomo‑Colli,Miguel A.; Zapata‑Tarres,Marta; Castelán‑Martínez,Osvaldo D.; Juárez‑Villegas,Luis E.; Córdova‑Hurtado,Lourdes P.

doi:10.3892/mco.2017.1533

A strategy for the clinical remission of acute lymphoblastic leukemia elicited by treatment of β‑thalassemia major: A case report

Authors:
- Miguel A. Palomo‑Colli
- Marta Zapata‑Tarres
- Osvaldo D. Castelán‑Martínez
- Luis E. Juárez‑Villegas
- Lourdes P. Córdova‑Hurtado
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Affiliations: Department of Oncology, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico, Department of Pediatric Oncology, Instituto Nacional de Pediatría, Mexico City 04530, Mexico, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City 09230, Mexico, Department of Hematology, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico
Published online on: December 8, 2017 https://doi.org/10.3892/mco.2017.1533
Pages: 375-377

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Abstract

Acute lymphoblastic leukemia (ALL) has been suggested as a long‑term complication in patients with β‑thalassemia major (β‑TM). A 12‑months‑old male patient was diagnosed with β‑TM. The patient required a blood transfusion weekly for 2 years. At the age of 4 years, a splenectomy was performed due to massive splenomegaly and frequent transfusion requirements. The histopathological analysis of the spleen revealed extensive hemosiderosis. ALL‑L1 with the T immunophenotype and without central nervous system (CNS) involvement was diagnosed when the patient was 5 years old, and treated with anti‑leukemic combination chemotherapy and CNS radiotherapy. The patient completed 24 months of treatment and has been in complete remission for 7 years, without long‑term adverse events.

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