Atypical diffuse bilateral cystic lung changes secondary to erlotinib treatment in a patient with metastatic non‑small cell lung carcinoma: A case report and literature review

  • Authors:
    • Jawaher Ansari
    • Enas Batubara
    • Muhammad Ali
    • Ashraf Farrag
    • Farhat Bashir
    • Hussein R. Farghaly
    • Arwa M. Ali
    • Arif Shaukat
  • View Affiliations

  • Published online on: May 4, 2018     https://doi.org/10.3892/mco.2018.1620
  • Pages: 92-95
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Abstract

Erlotinib is a first‑generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved in the first‑line treatment of advanced non‑small‑cell lung cancer (NSCLC) patients with sensitizing epidermal growth factor receptor (EGFR) mutations. The response rate to erlotinib is ~60% and the incidence of erlotinib‑induced interstitial lung disease (ILD) is ~1‑4%. The Response Evaluation Criteria in Solid Tumours (RECIST) tool is commonly used to assess response to erlotinib; however, evaluation of response and subsequent progression in the presence of atypical cystic lung changes may be challenging. We herein present a rare case of diffuse cystic lung changes secondary to erlotinib treatment in a patient with EGFR mutation‑positive metastatic NSCLC. Challenges in assessing atypical tumour response to erlotinib, pitfalls in using RECIST and differential diagnosis of TKI‑related ILD are discussed in detail.
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July-2018
Volume 9 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Ansari J, Batubara E, Ali M, Farrag A, Bashir F, Farghaly HR, Ali AM and Shaukat A: Atypical diffuse bilateral cystic lung changes secondary to erlotinib treatment in a patient with metastatic non‑small cell lung carcinoma: A case report and literature review. Mol Clin Oncol 9: 92-95, 2018
APA
Ansari, J., Batubara, E., Ali, M., Farrag, A., Bashir, F., Farghaly, H.R. ... Shaukat, A. (2018). Atypical diffuse bilateral cystic lung changes secondary to erlotinib treatment in a patient with metastatic non‑small cell lung carcinoma: A case report and literature review. Molecular and Clinical Oncology, 9, 92-95. https://doi.org/10.3892/mco.2018.1620
MLA
Ansari, J., Batubara, E., Ali, M., Farrag, A., Bashir, F., Farghaly, H. R., Ali, A. M., Shaukat, A."Atypical diffuse bilateral cystic lung changes secondary to erlotinib treatment in a patient with metastatic non‑small cell lung carcinoma: A case report and literature review". Molecular and Clinical Oncology 9.1 (2018): 92-95.
Chicago
Ansari, J., Batubara, E., Ali, M., Farrag, A., Bashir, F., Farghaly, H. R., Ali, A. M., Shaukat, A."Atypical diffuse bilateral cystic lung changes secondary to erlotinib treatment in a patient with metastatic non‑small cell lung carcinoma: A case report and literature review". Molecular and Clinical Oncology 9, no. 1 (2018): 92-95. https://doi.org/10.3892/mco.2018.1620