Assessment of redox biomarkers in the evaluation of the antioxidant profile in vitro and in vivo.

The approach of using redox biomarkers in the evaluation of the antioxidant profile both in vitro and in vivo has come on surface again lately. Although usually overlooked, recent scientific evidence indicates that redox biomarkers can become a useful tool with great translational potency in the field of redox biology. As they have been defined by Veskoukis et al 2019 (10.1016/j.cotox.2018.10.001), a redox biomarker might be an antioxidant molecule modified following interaction with reactive species, the products of the detrimental impact of reactive species on biomolecules and the reactive species per se. Furthermore, terms such as "oxidant" and "pro-oxidant" seem today rather vague as they have not been fully elucidated. On the same basis, the characterization of a compound as "antioxidant" is not sufficient since this term does not denote exactly the biological role of a given substance. Indeed, it is not clear whether the molecule in question prevents oxidation of biomolecules or repairs the oxidative modifications they have already undergone. Towards this end, redox biomarkers can putatively offer a valuable service in this area since, when functionally clustered, they might give the appropriate information for the actual role of an antioxidant. In this special issue, we invite the researchers to contribute both review papers and original research articles that will approach the issue of using biomarkers in order to evaluate on the one hand the antioxidant status of nutritional agents and plant extracts in vitro and on the other hand the redox status of a wide range of organisms in vivo. Potential topics include but are not limited to the following: Biomarkers used for the evaluation of in vivo antioxidant mechanisms Biomarkers for assessing the antioxidant activity of plant compounds in vitro Antioxidant status in disease using redox biomarkers Estimation of redox status in aging The role of redox biomarkers evaluating antioxidant status of a great variety of organisms in the past, present and future Redox biomarkers assessing antioxidant activity: the field of redox biology under a philosophical and historical aspect

01/06/2025