Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy

  • Authors:
    • Huabin Zheng
    • Zhuhong Zhang
    • Na Luo
    • Yuanyuan Liu
    • Qingzhong Chen
    • Hua Yan
  • View Affiliations

  • Published online on: August 5, 2014     https://doi.org/10.3892/mmr.2014.2448
  • Pages: 1954-1958
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

T helper 17 (Th17) cells are strong inducers of numerous autoimmune diseases and inflammation. However, the role of Th17 cells and interleukin (IL)‑17 in traumatic optic neuropathy (TON) are yet to be elucidated. In the present study, a rat model of TON was established using a fluid percussion brain injury device. Th17 cells were found to be upregulated in the spleens of rats in the TON group. In addition, the level of IL‑17 in the retina of rats in the TON group was observed to increase with the upregulation of the Th17 cells. Furthermore, the expression of IL‑17 in the optic nerve was found to be upregulated between one and seven days following injury in the rats in the TON group. These findings strongly suggest that the ratio of Th17 cells and the expression of IL‑17 are upregulated in rats with TON. These findings also provide a rationale for developing therapeutic agents to treat TON.
View Figures
View References

Related Articles

Journal Cover

October 2014
Volume 10 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zheng H, Zhang Z, Luo N, Liu Y, Chen Q and Yan H: Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy. Mol Med Rep 10: 1954-1958, 2014
APA
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., & Yan, H. (2014). Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy. Molecular Medicine Reports, 10, 1954-1958. https://doi.org/10.3892/mmr.2014.2448
MLA
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., Yan, H."Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy". Molecular Medicine Reports 10.4 (2014): 1954-1958.
Chicago
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., Yan, H."Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy". Molecular Medicine Reports 10, no. 4 (2014): 1954-1958. https://doi.org/10.3892/mmr.2014.2448