Altered function of monocytes/macrophages in patients with autoimmune hepatitis

Lin,Rui; Zhang,Jie; Zhou,Lu; Wang,Bangmao

doi:10.3892/mmr.2016.4998

Altered function of monocytes/macrophages in patients with autoimmune hepatitis

Authors:
- Rui Lin
- Jie Zhang
- Lu Zhou
- Bangmao Wang
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Affiliations: Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin 300052, P.R. China
Published online on: March 17, 2016 https://doi.org/10.3892/mmr.2016.4998
Pages: 3874-3880
Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The pathogenesis of autoimmune hepatitis (AIH) involves the intervention of the innate and adaptive immune responses. In the current study, the alterations in monocytes/Kupffer cells (KCs) were investigated in patients with AIH. A total of 21 patients with AIH at different stages of the disease, and 7 controls with non‑alcoholic fatty liver disease were selected. The abundance of VAV1 and p21‑activated kinase 1 (PAK1) in the liver and KCs was analyzed. In addition, the expression levels of HLA‑DR and CD80 in the peripheral blood monocytes (PBMs) were measured, and phagocytosis of PBMs was assessed. KCs of AIH patients exhibited higher expression levels of VAV1 and PAK1. This upregulated expression was associated with disease progression. A reduced expression of HLA‑DR and CD80, and reduced capacity of E. coli phagocytosis in PBMs was observed for patients with AIH. This downregulated expression was associated with disease progression. The results of the current study indicated that defective function of KCs and PBMs may be involved in the pathogenesis of AIH.

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