Open Access

Differential microRNA expression is associated with androgen receptor expression in breast cancer

  • Authors:
    • Yaqin Shi
    • Fang Yang
    • Zijia Sun
    • Wenwen Zhang
    • Jun Gu
    • Xiaoxiang Guan
  • View Affiliations

  • Published online on: December 9, 2016     https://doi.org/10.3892/mmr.2016.6019
  • Pages: 29-36
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The androgen receptor (AR) is frequently expressed in breast cancer; however, its prognostic value remains unclear. AR expression in breast cancer has been associated with improved outcomes in estrogen receptor (ER)‑positive breast cancer compared with ER‑negative disease. Eliminating AR function in breast cancer is critically important for breast cancer progression. However, the mechanism underlying AR regulation remains poorly understood. The study of microRNAs (miRNAs) has provided important insights into the pathogenesis of hormone‑dependent cancer. To determine whether miRNAs function in the AR regulation of breast cancer, the present study performed miRNA expression profiling in AR‑positive and ‑negative breast cancer cell lines. A total of 153 miRNAs were differentially expressed in AR‑positive compared with AR‑negative breast cancer cells; 52 were upregulated and 101 were downregulated. A number of these have been extensively associated with breast cancer cell functions, including proliferation, invasion and drug‑resistance. Furthermore, through pathway enrichment analysis, signaling pathways associated with the prediction targets of the miRNAs were characterized, including the vascular endothelial growth factor and mammalian target of rapamycin signaling pathways. In conclusion, the results of the present study indicated that the expression of miRNAs may be involved in the mechanism underlying AR regulation of breast cancer, and may improve understanding of the role of AR in breast cancer.
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January-2017
Volume 15 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Shi Y, Yang F, Sun Z, Zhang W, Gu J and Guan X: Differential microRNA expression is associated with androgen receptor expression in breast cancer. Mol Med Rep 15: 29-36, 2017
APA
Shi, Y., Yang, F., Sun, Z., Zhang, W., Gu, J., & Guan, X. (2017). Differential microRNA expression is associated with androgen receptor expression in breast cancer. Molecular Medicine Reports, 15, 29-36. https://doi.org/10.3892/mmr.2016.6019
MLA
Shi, Y., Yang, F., Sun, Z., Zhang, W., Gu, J., Guan, X."Differential microRNA expression is associated with androgen receptor expression in breast cancer". Molecular Medicine Reports 15.1 (2017): 29-36.
Chicago
Shi, Y., Yang, F., Sun, Z., Zhang, W., Gu, J., Guan, X."Differential microRNA expression is associated with androgen receptor expression in breast cancer". Molecular Medicine Reports 15, no. 1 (2017): 29-36. https://doi.org/10.3892/mmr.2016.6019