Open Access

The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma

  • Authors:
    • Moyu Ming
    • Chaoqian Li
    • Zhixi Luo
    • Shengqiu Lv
    • Qixiang Sun
  • View Affiliations

  • Published online on: December 29, 2016     https://doi.org/10.3892/mmr.2016.6087
  • Pages: 777-783
  • Copyright: © Ming et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Allergic asthma is a chronic airway disorder characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR). A murine model of asthma was used to examine the antiasthmatic effect of inhaled inactived Mycobacterium phlei (M. phlei). AHR, neutrophil levels, eosinophil levels and levels of interleukin (IL)‑17 and IL‑23 receptor (IL‑23R) were monitored. The results demonstrated that inactivated M. phlei alleviates the IL‑17+γδT cell‑mediated immune response and attenuates airway inflammation and airway hyperresponsiveness in the asthmatic murine lung, partially through inhibiting the expression of IL‑23R. In conclusion, inactivated M. phlei may be an effective antiasthmatic treatment, regulating IL‑17‑producing γδT (IL‑17+γδT) cell‑mediated airway inflammation and airway hyperresponsiveness to relieve the symptoms of mice with asthma.
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February-2017
Volume 15 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ming M, Li C, Luo Z, Lv S and Sun Q: The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma. Mol Med Rep 15: 777-783, 2017
APA
Ming, M., Li, C., Luo, Z., Lv, S., & Sun, Q. (2017). The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma. Molecular Medicine Reports, 15, 777-783. https://doi.org/10.3892/mmr.2016.6087
MLA
Ming, M., Li, C., Luo, Z., Lv, S., Sun, Q."The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma". Molecular Medicine Reports 15.2 (2017): 777-783.
Chicago
Ming, M., Li, C., Luo, Z., Lv, S., Sun, Q."The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma". Molecular Medicine Reports 15, no. 2 (2017): 777-783. https://doi.org/10.3892/mmr.2016.6087