Open Access

MicroRNA‑141 inhibits the self‑renewal of glioblastoma stem cells via Jagged1

  • Authors:
    • Xianfeng Gao
    • Xiaobo Zhu
    • Yang Sun
    • Jingwei Liu
  • View Affiliations

  • Published online on: May 17, 2017     https://doi.org/10.3892/mmr.2017.6598
  • Pages: 167-173
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma multiforme is one of the most lethal types of brain cancer. With limited success from conventional therapies, the cancer stem cell theory was developed, and investigation into microRNAs (miRs) has facilitated understanding of this theory. The present study demonstrated that miR‑141 is suppressed in sorted cluster of differentiation (CD) 133(+) glioblastoma stem cells (GSCs) compared with CD133(‑) non‑glioblastoma stem cells (NSCs) from patient samples. In addition, miR‑141 overexpression inhibited the sphere formation ability of GSCs in vitro and in vivo. Furthermore, Jagged1 may reverse the effect of miR‑141; miR‑141 was revealed to target the 3'‑untranslated region of Jagged1, thereby inhibiting the stemness of GSCs. Thus, miR‑141 may serve as a potent antioncomir targeting cancer stem cells, and may facilitate the development of therapeutic targets to prolong the overall survival of patients with glioblastoma.
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July-2017
Volume 16 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Gao X, Zhu X, Sun Y and Liu J: MicroRNA‑141 inhibits the self‑renewal of glioblastoma stem cells via Jagged1. Mol Med Rep 16: 167-173, 2017
APA
Gao, X., Zhu, X., Sun, Y., & Liu, J. (2017). MicroRNA‑141 inhibits the self‑renewal of glioblastoma stem cells via Jagged1. Molecular Medicine Reports, 16, 167-173. https://doi.org/10.3892/mmr.2017.6598
MLA
Gao, X., Zhu, X., Sun, Y., Liu, J."MicroRNA‑141 inhibits the self‑renewal of glioblastoma stem cells via Jagged1". Molecular Medicine Reports 16.1 (2017): 167-173.
Chicago
Gao, X., Zhu, X., Sun, Y., Liu, J."MicroRNA‑141 inhibits the self‑renewal of glioblastoma stem cells via Jagged1". Molecular Medicine Reports 16, no. 1 (2017): 167-173. https://doi.org/10.3892/mmr.2017.6598