Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity

  • Authors:
    • Junjiang Chen
    • Lianqun Cui
    • Jingliang Yuan
    • Songcun Zhang
    • Rongmei Ma
    • Hongjun Sang
    • Qingjiang Liu
    • Lianfeng Shan
  • View Affiliations

  • Published online on: August 3, 2017     https://doi.org/10.3892/mmr.2017.7152
  • Pages: 4791-4796
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Abstract

The present study aimed to investigate whether diminazene attenuates myocardial infarction (MI) in rats. In addition, the present study investigated whether ACE2 signaling was involved in the effects of diminazene on protein function. A rat model of acute myocardial infarction (AMI) was established by occlusion of the left anterior descending coronary artery. The AMI model rats received intraperitoneal injections of diminazene (5 mg/kg/day) for 3 days. Treatment with diminazene significantly inhibited the expression of casein kinase and lactate dehydrogenase, and reduced infarct size in AMI rats. The findings indicated that diminazene significantly reduced the levels of inflammatory factors including tumor necrosis factor‑α and interleukin‑6, suppressed the protein expression of cytochrome c oxidase subunit 2 (COX‑2) and inducible nitric oxide synthase (iNOS), and activated angiotensin‑converting enzyme 2 (ACE2), angiotensin II receptor type 1 (AT1R) and MAS1 proto‑oncogene, G protein‑coupled receptor (MasR) protein expression in AMI model rats. In conclusion, the present study demonstrated that diminazene attenuated AMI in rats via suppression of inflammation, reduction of COX‑2 and iNOS expression, and activation of the ACE2/AT1R/MasR signaling pathway.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen J, Cui L, Yuan J, Zhang S, Ma R, Sang H, Liu Q and Shan L: Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity. Mol Med Rep 16: 4791-4796, 2017.
APA
Chen, J., Cui, L., Yuan, J., Zhang, S., Ma, R., Sang, H. ... Shan, L. (2017). Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity. Molecular Medicine Reports, 16, 4791-4796. https://doi.org/10.3892/mmr.2017.7152
MLA
Chen, J., Cui, L., Yuan, J., Zhang, S., Ma, R., Sang, H., Liu, Q., Shan, L."Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity". Molecular Medicine Reports 16.4 (2017): 4791-4796.
Chicago
Chen, J., Cui, L., Yuan, J., Zhang, S., Ma, R., Sang, H., Liu, Q., Shan, L."Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity". Molecular Medicine Reports 16, no. 4 (2017): 4791-4796. https://doi.org/10.3892/mmr.2017.7152