Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity

  • Authors:
    • Quan-Yong Huang
    • Xue-Fang Li
    • Shui-Ping Liu
  • View Affiliations

  • Published online on: December 13, 2011     https://doi.org/10.3892/mmr.2011.706
  • Pages: 651-654
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Abstract

Cisplatin-induced heart damage is associated with enzymes and protein alterations. The purpose of this study was to investigate cisplatin-induced alterations in cardiac endothelin (ET)-1 and type III collagen following administration of cisplatin. Male Wistar rats were randomly divided into two groups: a control and a cisplatin group. The cisplatin group received cisplatin intraperitoneally (i.p.) at a single dose of 7 mg/kg on day 6, while the controls were given the same amount of saline via the same route. On day 11, the rats were anesthetized and a thoracotomy was performed on all animals. Immunohistochemical analysis was performed to evaluate the protein expression of ET-1 and type III collagen. Sections were analyzed by digital image analysis. Results showed that the cardiac protein expression of ET-1 and type III collagen was altered following cisplatin-induced toxicity in rats. The expression of ET-1 and type III collagen was significantly increased after cisplatin treatment, supported by integrated optical density, when compared to the control group (P<0.05). The present findings indicate that such alterations may be reflected in abnormal cardiac function. Additionally, the proteins identified in this study may benefit investigations into the mechanisms underlying cisplatin-induced toxicity, thereby providing the necessary evidence for further research.

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March 2012
Volume 5 Issue 3

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Spandidos Publications style
Huang Q, Li X and Liu S: Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity. Mol Med Rep 5: 651-654, 2012.
APA
Huang, Q., Li, X., & Liu, S. (2012). Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity. Molecular Medicine Reports, 5, 651-654. https://doi.org/10.3892/mmr.2011.706
MLA
Huang, Q., Li, X., Liu, S."Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity". Molecular Medicine Reports 5.3 (2012): 651-654.
Chicago
Huang, Q., Li, X., Liu, S."Endothelin-1 and type III collagen alterations in the heart of rats following cisplatin-induced toxicity". Molecular Medicine Reports 5, no. 3 (2012): 651-654. https://doi.org/10.3892/mmr.2011.706