Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats

  • Authors:
    • Hongwei Li
    • Zhenhai Shen
    • Yun Lu
    • Feng Lin
    • Yawen Wu
    • Zhongli Jiang
  • View Affiliations

  • Published online on: May 2, 2012     https://doi.org/10.3892/mmr.2012.897
  • Pages: 69-74
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Abstract

The aim of the present study was to explore the role of exercise in diabetic peripheral neuropathy (DPN) and the mechanisms involved. For this purpose, 31 male Sprague-Dawley rats were used. The rats were assigned to 5 groups: diabetic rats subjected to exercise training (swimming) for 8 weeks (D-Ex1 group), diabetic rats subjected to exercise training for 4 weeks after 4 weeks of being sedentary (D-Ex2 group), diabetic rats which remained sedentary for 8 weeks (D-Sed group), control rats subjected to exercise training for 8 weeks (C-Ex1 group) and control rats which remained sedentary for 8 weeks (C-Sed group). Blood glucose levels and caudal nerve conduction velocity (NCV) were evaluated at 0 (baseline), 28 (4 weeks) and 56 days (8 weeks) after the induction of diabetes. The levels of neurotrophin-3 (NT-3) in skeletal muscle were measured by ELISA at the end of the experiment. Blood glucose levels in the D-Ex1 group rats decreased significantly after 8 weeks of exercise. The caudal NCV markedly decreased in all diabetic rats and significantly increased after 4 or 8 weeks of exercise training. Muscle NT-3 levels were significantly lower in the D-Sed compared to the 4 other groups. Muscle NT-3 levels positively correlated with caudal NCV. In conclusion, swimming training has a beneficial effect on DPN and muscle NT-3 levels, which could help improve caudal NCV in streptozotocin-induced diabetic rats.

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July 2012
Volume 6 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li H, Shen Z, Lu Y, Lin F, Wu Y and Jiang Z: Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats. Mol Med Rep 6: 69-74, 2012.
APA
Li, H., Shen, Z., Lu, Y., Lin, F., Wu, Y., & Jiang, Z. (2012). Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats. Molecular Medicine Reports, 6, 69-74. https://doi.org/10.3892/mmr.2012.897
MLA
Li, H., Shen, Z., Lu, Y., Lin, F., Wu, Y., Jiang, Z."Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats". Molecular Medicine Reports 6.1 (2012): 69-74.
Chicago
Li, H., Shen, Z., Lu, Y., Lin, F., Wu, Y., Jiang, Z."Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats". Molecular Medicine Reports 6, no. 1 (2012): 69-74. https://doi.org/10.3892/mmr.2012.897