Open Access

Interplay between unfolded protein response and autophagy promotes tumor drug resistance (Review)

  • Authors:
    • Ming‑Ming Yan
    • Jiang‑Dong Ni
    • Deye Song
    • Muliang Ding
    • Jun Huang
  • View Affiliations

  • Published online on: July 17, 2015     https://doi.org/10.3892/ol.2015.3508
  • Pages: 1959-1969
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The endoplasmic reticulum (ER) is involved in the quality control of secreted protein via promoting the correct folding of nascent protein and mediating the degradation of unfolded or misfolded protein, namely ER‑associated degradation. When the unfolded or misfolded proteins are abundant, the unfolded protein response (UPR) is elicited, an adaptive signaling cascade from the ER to the nucleus, which restores the homeostatic functions of the ER. Autophagy is a conserved catabolic process where cellular long‑lived proteins and damaged organelles are engulfed and degraded for recycling to maintain homeostasis. The UPR and autophagy occur simultaneously and are involved in pathological processes, including tumorigenesis, chemoresistance of malignancies and neurodegeneration. Accumulative data has indicated that the UPR may induce autophagy and that autophagy is able to alleviate the UPR. However, the detailed mechanism of interplay between autophagy and UPR remains to be fully understood. The present review aimed to depict the core pathways of the two processes and to elucidate how autophagy and UPR are regulated. Moreover, the review also discusses the molecular mechanism of crosstalk between the UPR and autophagy and their roles in malignant survival and drug resistance.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yan MM, Ni JD, Song D, Ding M and Huang J: Interplay between unfolded protein response and autophagy promotes tumor drug resistance (Review). Oncol Lett 10: 1959-1969, 2015
APA
Yan, M., Ni, J., Song, D., Ding, M., & Huang, J. (2015). Interplay between unfolded protein response and autophagy promotes tumor drug resistance (Review). Oncology Letters, 10, 1959-1969. https://doi.org/10.3892/ol.2015.3508
MLA
Yan, M., Ni, J., Song, D., Ding, M., Huang, J."Interplay between unfolded protein response and autophagy promotes tumor drug resistance (Review)". Oncology Letters 10.4 (2015): 1959-1969.
Chicago
Yan, M., Ni, J., Song, D., Ding, M., Huang, J."Interplay between unfolded protein response and autophagy promotes tumor drug resistance (Review)". Oncology Letters 10, no. 4 (2015): 1959-1969. https://doi.org/10.3892/ol.2015.3508