Open Access

IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review)

  • Authors:
    • Alessandro Morotti
    • Sabrina Crivellaro
    • Cristina Panuzzo
    • Giovanna Carrà
    • Angelo Guerrasio
    • Giuseppe Saglio
  • View Affiliations

  • Published online on: December 6, 2016     https://doi.org/10.3892/ol.2016.5465
  • Pages:531-534
  • Copyright: © Morotti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nuclear factor κB (NF‑κB) is an essential component of tumorigenesis and resistance to cancer treatments. NFKB inhibitor α (IκB‑α) acts as a negative regulator of the classical NF‑κB pathway through its ability to maintain the presence of NF‑κB in the cytoplasm. However, IκB‑α is also able to form a complex with tumor protein p53, promoting its inactivation. Recently, we demonstrated that IκB‑α is able to mediate p53 nuclear exclusion and inactivation in chronic myeloid leukemia, indicating that IκB‑α can modulate either oncogenic or tumor‑suppressive functions, with important implications for cancer treatment. The present review describes the role of IκB‑α in cancer pathogenesis, with particular attention to hematological cancers, and highlights the involvement of IκB‑α in the regulation of p53 tumor‑suppressive functions.

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February 2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

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APA
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., & Saglio, G. (2017). IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review). Oncology Letters, 13, 531-534. https://doi.org/10.3892/ol.2016.5465
MLA
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., Saglio, G."IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review)". Oncology Letters 13.2 (2017): 531-534.
Chicago
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., Saglio, G."IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review)". Oncology Letters 13, no. 2 (2017): 531-534. https://doi.org/10.3892/ol.2016.5465