Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism
- Jianchang Li
- Mingning Qiu
- Lieqian Chen
- Lei Liu
- Guobin Tan
- Jianjun Liu
Published online on: December 20, 2016
Copyright: © Li et al.
This is an open access article distributed under the terms of Creative Commons Attribution License.
The aim of the present study was to investigate the effect of resveratrol on renal carcinoma cells and explore possible renin‑angiotensin system‑associated mechanisms. Subsequent to resveratrol treatment, the cell viability, apoptosis rate, cytotoxicity levels, caspase 3/7 activity and the levels of angiotensin II (AngII), AngII type 1 receptor (AT1R), vascular endothelial growth factor (VEGF) and cyclooxygenase‑2 (COX‑2) were evaluated in renal carcinoma cells. The effects of AngII, AT1R, VEGF and COX‑2 on resveratrol‑induced cell growth inhibition and apoptosis were also examined. The results indicated that resveratrol treatment may suppress growth, induce apoptosis, and decrease AngII, AT1R, VEGF and COX‑2 levels in renal carcinoma ACHN and A498 cells. In addition, resveratrol‑induced cell growth suppression and apoptosis were reversed when co‑culturing with AT1R or VEGF. Thus, resveratrol may suppress renal carcinoma cell proliferation and induce apoptosis via an AT1R/VEGF pathway.