Open Access

Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model

  • Authors:
    • Meng Wang
    • Shi‑Ju Yan
    • Hong‑Tao Zhang
    • Nan Li
    • Tao Liu
    • Ying‑Long  Zhang
    • Xiao‑Xiang Li
    • Qiong Ma
    • Xiu‑Chun Qiu
    • Qing‑Yu Fan
    • Bao‑An Ma
  • View Affiliations

  • Published online on: December 12, 2016     https://doi.org/10.3892/ol.2016.5490
  • Pages:681-685
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The treatment of malignant tumors following surgery is important in preventing relapse. Among all the post‑surgery treatments, immunomodulators have demonstrated satisfactory effects on preventing recurrence according to recent studies. Ginsenoside is a compound isolated from panax ginseng, which is a famous traditional Chinese medicine. Ginsenoside aids in killing tumor cells through numerous processes, including the antitumor processes of ginsenoside Rh2 and Rg1, and also affects the inflammatory processes of the immune system. However, the role that ginsenoside serves in antitumor immunological activity remains to be elucidated. Therefore, the present study aimed to analyze the effect of ginsenoside Rh2 on the antitumor immunological response. With a melanoma mice model, ginsenoside Rh2 was demonstrated to inhibit tumor growth and improved the survival time of the mice. Ginsenoside Rh2 enhanced T‑lymphocyte infiltration in the tumor and triggered cytotoxicity in spleen lymphocytes. In addition, the immunological response triggered by ginsenoside Rh2 could be transferred to other mice. In conclusion, the present study provides evidence that ginsenoside Rh2 treatment enhanced the antitumor immunological response, which may be a potential therapy for melanoma.

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February 2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2015 Impact Factor: 1.482
Ranked #97/211 Oncology
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Copy and paste a formatted citation
APA
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y. ... Ma, B. (2017). Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model. Oncology Letters, 13, 681-685. https://doi.org/10.3892/ol.2016.5490
MLA
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y., Li, X., Ma, Q., Qiu, X., Fan, Q., Ma, B."Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model". Oncology Letters 13.2 (2017): 681-685.
Chicago
Wang, M., Yan, S., Zhang, H., Li, N., Liu, T., Zhang, Y., Li, X., Ma, Q., Qiu, X., Fan, Q., Ma, B."Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model". Oncology Letters 13, no. 2 (2017): 681-685. https://doi.org/10.3892/ol.2016.5490