Single nucleotide polymorphisms of the haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination

  • Authors:
    • Kayoko Waki
    • Teppei Yamada
    • Koichi Yoshiyama
    • Yasuhiro Terazaki
    • Shinjiro Sakamoto
    • Shunichi Sugawara
    • Shinzo Takamori
    • Kyogo Itoh
    • Akira Yamada
  • View Affiliations

  • Published online on: December 7, 2016     https://doi.org/10.3892/ol.2016.5467
  • Pages: 993-999
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Abstract

The present study analyzed polymorphisms of the 5' flanking region (from nt ‑840 to +151) of the haptoglobin gene in 120 patients with advanced non-small cell lung cancer (NSCLC) receiving personalized peptide vaccinations. In the region, six single nucleotide polymorphisms (SNPs) were confirmed, of which two, rs5472 and rs9927981, were completely linked to each other. The minor allele frequencies of rs5472/rs9927981 and rs4788458 were higher than those of the other three SNPs. The genotype frequencies of rs5472 or rs9927981 were A/A or C/C (42.5%, n=51), A/G or C/T (40.8%, n=49), and G/G or T/T (16.7%, n=20), respectively; and those of rs4788458 were T/T (34.2%, n=41), T/C (40.0%, n=48), and C/C (25.8%, n=31). The association between polymorphism rs5472/rs9927981 and prognosis, or between rs4788458 and prognosis, was analyzed further. However, no correlation was found between these SNPs and overall survival, regardless of subgroup analysis of gender, histology or concurrent therapy. These results suggest that the polymorphisms rs5472/rs9927981 and rs4788458 are not useful prognostic tools for patients with NSCLC treated with personalized peptide vaccination.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Waki K, Yamada T, Yoshiyama K, Terazaki Y, Sakamoto S, Sugawara S, Takamori S, Itoh K and Yamada A: Single nucleotide polymorphisms of the haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination. Oncol Lett 13: 993-999, 2017
APA
Waki, K., Yamada, T., Yoshiyama, K., Terazaki, Y., Sakamoto, S., Sugawara, S. ... Yamada, A. (2017). Single nucleotide polymorphisms of the haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination. Oncology Letters, 13, 993-999. https://doi.org/10.3892/ol.2016.5467
MLA
Waki, K., Yamada, T., Yoshiyama, K., Terazaki, Y., Sakamoto, S., Sugawara, S., Takamori, S., Itoh, K., Yamada, A."Single nucleotide polymorphisms of the haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination". Oncology Letters 13.2 (2017): 993-999.
Chicago
Waki, K., Yamada, T., Yoshiyama, K., Terazaki, Y., Sakamoto, S., Sugawara, S., Takamori, S., Itoh, K., Yamada, A."Single nucleotide polymorphisms of the haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination". Oncology Letters 13, no. 2 (2017): 993-999. https://doi.org/10.3892/ol.2016.5467