Open Access

Downregulation of EGFR in a metastatic brain lesion of EGFR-mutated non-small cell lung cancer using a tyrosine kinase inhibitor: A case report

  • Authors:
    • Masatoshi Takagaki
    • Manabu Kinoshita
    • Kazumi Nishino
    • Masakazu Nakano
    • Hiroko Adachi
    • Morio Ueno
    • Masanori Kitamura
    • Yasunori Fujimoto
    • Kei Tashiro
    • Yasuhiko Tomita
    • Fumio Imamura
    • Toshiki Yoshimine
  • View Affiliations

  • Published online on: February 6, 2017     https://doi.org/10.3892/ol.2017.5677
  • Pages:2085-2088
  • Copyright: © Takagaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Brain metastasis is a common complication in patients with cancer, with lung cancer being the most frequent origin of brain metastases. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have begun to serve a pivotal role in lung cancer treatment and have been reported to demonstrate anticancer activity against brain metastases by penetrating the blood‑brain barrier. The present study reports, to the best of our knowledge, the first case of EGFR‑mutated non‑small cell lung cancer (NSCLC) brain metastasis that was surgically resected while the lesion was responding to the EGFR‑TKI erlotinib. The results of the present study demonstrated that EGFR-mutated NSCLC cells were able to evade the cytotoxic effect of EGFR-TKI by downregulating EGFR expression, without exhibiting the T790M EGFR mutation.

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April 2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

2015 Impact Factor: 1.482
Ranked #97/211 Oncology
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Copy and paste a formatted citation
APA
Takagaki, M., Kinoshita, M., Nishino, K., Nakano, M., Adachi, H., Ueno, M. ... Yoshimine, T. (2017). Downregulation of EGFR in a metastatic brain lesion of EGFR-mutated non-small cell lung cancer using a tyrosine kinase inhibitor: A case report. Oncology Letters, 13, 2085-2088. https://doi.org/10.3892/ol.2017.5677
MLA
Takagaki, M., Kinoshita, M., Nishino, K., Nakano, M., Adachi, H., Ueno, M., Kitamura, M., Fujimoto, Y., Tashiro, K., Tomita, Y., Imamura, F., Yoshimine, T."Downregulation of EGFR in a metastatic brain lesion of EGFR-mutated non-small cell lung cancer using a tyrosine kinase inhibitor: A case report". Oncology Letters 13.4 (2017): 2085-2088.
Chicago
Takagaki, M., Kinoshita, M., Nishino, K., Nakano, M., Adachi, H., Ueno, M., Kitamura, M., Fujimoto, Y., Tashiro, K., Tomita, Y., Imamura, F., Yoshimine, T."Downregulation of EGFR in a metastatic brain lesion of EGFR-mutated non-small cell lung cancer using a tyrosine kinase inhibitor: A case report". Oncology Letters 13, no. 4 (2017): 2085-2088. https://doi.org/10.3892/ol.2017.5677