Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report

Luo,Xin‑Yu; Wang,Jue; Zhao,Jia; Chen,Rui; Zha,Xiao‑Ming

doi:10.3892/ol.2017.6158

Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report

Authors:
- Xin‑Yu Luo
- Jue Wang
- Jia Zhao
- Rui Chen
- Xiao‑Ming Zha
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Affiliations: Department of Breast Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
Published online on: May 11, 2017 https://doi.org/10.3892/ol.2017.6158
Pages: 31-34
Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer has the highest rate of incidence among all types of cancer in women. Only ~0.43% of breast malignancies occur as a result of metastatic lesions from extramammary tumors. The present study reports an extremely rare case of transverse colon cancer metastasizing to the bilateral ovaries and the left breast. The patient was a 47-year old female, who had a lump in the left breast without axillary lymphadenopathy. Specimens obtained by core needle biopsy were submitted for hematoxylin and eosin examination, and results revealed that the lump was a poorly differentiated adenocarcinoma. Since the patient had elevated levels of the carcinoembryonic antigen and a medical history of a Krukenberg tumor metastasized from colon cancer, immunohistochemical examinations were applied. Results identified that caudal‑related homeobox protein 2 and cytokeratin 20 were positively stained, whilst cytokeratin 7 was negatively stained. Therefore, this patient was diagnosed as having colon cancer that had metastasized to the bilateral ovaries and the left breast. As the life expectancy of patients with cancer is increasing, types of metastases that used to be seen as rare are increasingly becoming more common. For clinicians, diagnosis should be cautious, and differential diagnosis should always be kept in mind.

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1	Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI
2	Georgiannos SN, Chin J, Goode AW and Sheaff M: Secondary neoplasms of the breast: A survey of the 20th century. Cancer. 92:2259–2266. 2001. View Article : Google Scholar : PubMed/NCBI
3	Ahmad A, Baiden-Amissah K, Oyegade A, Absar M, Swainson K and Titi S: Primary sigmoid adenocarcinoma metastasis to the breast in a 28-year-old female: A case study and a review of literature. Korean J Pathol. 48:58–61. 2014. View Article : Google Scholar : PubMed/NCBI
4	McIntosh IH, Hooper AA, Millis RR and Greening WP: Metastatic carcinoma within the breast. Clin Oncol. 2:393–401. 1976.PubMed/NCBI
5	Mendelson E, Bohm-Velez M, Berg W, et al: ACR BI-RADS^® ultrasoundAtlas, Breast Imaging Reporting and Data System American College of Radiology. Reston VA: pp. 1492013
6	Selcukbiricik F, Tural D, Bay A, Sahingoz G, Ilvan S and Mandel NM: A malignant mass in the breast is not always breast cancer. Case Rep Oncol. 4:521–525. 2011. View Article : Google Scholar : PubMed/NCBI
7	Israel SL, Helsel EV Jr and Hausman DH: The challenge of metastatic ovarian carcinoma. Am J Obstet Gynecol. 93:1094–1101. 1965. View Article : Google Scholar : PubMed/NCBI
8	Jiang R, Tang J, Cheng X and Zang RY: Surgical treatment for patients with different origins of Krukenberg tumors: Outcomes and prognostic factors. Eur J Surg Oncol. 35:92–97. 2009. View Article : Google Scholar : PubMed/NCBI
9	Jiang Q, Liu S, Xiong H, Pen J, Cai K, Yang Y and Xiong Z: Metastatic signet ring cell carcinoma of the bilateral breasts and ovaries from gastrointestinal tract in a young breastfeeding female - a case report. J Cancer. 2:484–489. 2011. View Article : Google Scholar : PubMed/NCBI
10	Vakili SM, Sharbatdaran M, Noorbaran A, Siadati S, Moslemi D and Shafahi S: A case of colon cancer with breast metastasis and krukenberg tumor. Int J Hematol Oncol Stem Cell Res. 8:46–50. 2014.PubMed/NCBI
11	Noh KT, Oh B, Sung SH, Lee RA, Chung SS, Moon BI and Kim KH: Metastasis to the breast from colonic adenocarcinoma. J Korean Surg Soc. 81 Suppl 1:S43–S46. 2011. View Article : Google Scholar : PubMed/NCBI
12	Fernández de Bobadilla L, García Villanueva A, Collado M, De Juan A, Rojo R, Pérez J, Lisa E, Aguilera A, Mena A and González-Palacios F: Breast metastasis of primary colon cancer. Rev Esp Enferm Dig. 96:415–419. 2004.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI
13	Vergier B, Trojani M, De Mascarel I, Coindre JM and Le Treut A: Metastases to the breast: Differential diagnosis from primary breast carcinoma. J Surg Oncol. 48:112–116. 1991. View Article : Google Scholar : PubMed/NCBI
14	Hajdu SI and Urban JA: Cancers metastatic to the breast. Cancer. 29:1691–1696. 1972. View Article : Google Scholar : PubMed/NCBI
15	Williams SA, Ehlers RA II, Hunt KK, Yi M, Kuerer HM, Singletary SE, Ross MI, Feig BW, Symmans WF and Meric-Bernstam F: Metastases to the breast from nonbreast solid neoplasms: Presentation and determinants of survival. Cancer. 110:731–737. 2007. View Article : Google Scholar : PubMed/NCBI
16	Vizcaino I, Torregrosa A, Higueras V, Morote V, Cremades A, Torres V, Olmos S and Molins C: Metastasis to the breast from extramammary malignancies: A report of four cases and a review of literature. Eur Radiol. 11:1659–1665. 2011. View Article : Google Scholar
17	Ho YY and Lee WK: Metastasis to the breast from an adenocarcinoma of the colon. J Clin Ultrasound. 37:239–241. 2009. View Article : Google Scholar : PubMed/NCBI
18	Kende AI, Carr NJ and Sobin LH: Expression of cytokeratins 7 and 20 in carcinomas of the gastrointestinal tract. Histopathology. 42:137–140. 2003. View Article : Google Scholar : PubMed/NCBI
19	Park SY, Kim BH, Kim JH, Lee S and Kang GH: Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma. Arch Pathol Lab Med. 131:1561–1567. 2007.PubMed/NCBI
20	Werling RW, Yaziji H, Bacchi CE and Gown AM: CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: An immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 27:303–310. 2003. View Article : Google Scholar : PubMed/NCBI