Negative feedback loop between ZBTB7A and TGF‑β in breast cancer

Shen,Yingying; Cao,Renxian; Liu,Wen; Zhou,Yuqing; Wu,Ying; Tan,Jingjing; Jin,Min; Zhong,Jing; Zhang,Qinghai; Liu,Jianghua; Zu,Xuyu

doi:10.3892/ol.2017.6291

Negative feedback loop between ZBTB7A and TGF‑β in breast cancer

Authors:
- Yingying Shen
- Renxian Cao
- Wen Liu
- Yuqing Zhou
- Ying Wu
- Jingjing Tan
- Min Jin
- Jing Zhong
- Qinghai Zhang
- Jianghua Liu
- Xuyu Zu
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Affiliations: Institute of Clinical Medicine, The First Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China, Department of Metabolism and Endocrinology, The First Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China
Published online on: June 1, 2017 https://doi.org/10.3892/ol.2017.6291
Pages: 1403-1410
Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Zinc finger and BTB domain containing 7A (ZBTB7A) is aberrantly expressed in breast cancer, but the involvement of ZBTB7A in breast cancer remains controversial. Transforming growth factor‑β (TGF‑β) is a pleiotropic cytokine which promotes breast cancer metastasis. ZBTB7A and TGF‑β are important factors in tumor development. However, the association between ZBTB7A and TGF‑β in breast cancer remains unknown. The results of the present study revealed that TGF‑β1 induced the expression of ZBTB7A via the phosphoinositide 3‑kinase‑protein kinase B signaling pathway in human breast cancer cells, and ZBTB7A inhibited the expression of TGF‑β1 through indirectly suppressing the promoter activity of TGF‑β1. Furthermore, no significant correlation between the expression of ZBTB7A and TGF‑β1 were identified in breast cancer tissues using tissue microarray assay and human cancer genomics analysis. These results have identified a negative feedback loop between ZBTB7A and TGF‑β signaling, suggesting ZBTB7A as a potential modulator of breast cancer metastasis. Thus, the results of the present study suggested that ZBTB7A is a potential prognostic biomarker for breast cancer.

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