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Application values of 99mTc‑methoxyisobutylisonitrile imaging for differentiating benign and malignant thymic masses

  • Authors:
    • Chenghui Lu
    • Xufu Wang
    • Bin Liu
    • Xinfeng Liu
    • Guoming Wang
    • Qin Zhang

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  • Published online on: June 21, 2017     https://doi.org/10.3892/ol.2017.6447
  • Pages: 2417-2421
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Abstract

The aim of the present study was to investigate the application value of 99mTc-methoxyisobutylisonitrile (MIBI) imaging to differentiate between benign and malignant thymic masses. A total of 32 patients with space‑occupying mediastinal masses were enrolled and early and delayed‑phase images were collected following injection with the imaging agent. The tumor to background ratio (T/N) values at the different phases were also recorded. The sensitivity of the qualitative analysis to distinguish between benign and malignant thymic masses was 95.24%, with specificity as 90.91%. The T/N values in the early and delayed phases were not significantly different in the group with benign thymic masses, but demonstrated statistical significant differences in the groups with low‑ and intermediate‑grade malignant thymic masses. The T/N values at the above early and delayed phase were significantly different between the benign and low‑grade malignancy groups, as well as between low‑ and moderate‑grade malignancy groups. Those between the benign and moderate‑grade malignancy groups demonstrated no significant difference. 99mTc‑MIBI imaging was able to differentiate between benign and malignant thymic masses, and the simultaneous semi‑quantitative analysis of the T/N values of the tumors may be able to initially determine the degree of malignancy of thymoma.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lu C, Wang X, Liu B, Liu X, Wang G and Zhang Q: Application values of 99mTc‑methoxyisobutylisonitrile imaging for differentiating benign and malignant thymic masses. Oncol Lett 14: 2417-2421, 2017.
APA
Lu, C., Wang, X., Liu, B., Liu, X., Wang, G., & Zhang, Q. (2017). Application values of 99mTc‑methoxyisobutylisonitrile imaging for differentiating benign and malignant thymic masses. Oncology Letters, 14, 2417-2421. https://doi.org/10.3892/ol.2017.6447
MLA
Lu, C., Wang, X., Liu, B., Liu, X., Wang, G., Zhang, Q."Application values of 99mTc‑methoxyisobutylisonitrile imaging for differentiating benign and malignant thymic masses". Oncology Letters 14.2 (2017): 2417-2421.
Chicago
Lu, C., Wang, X., Liu, B., Liu, X., Wang, G., Zhang, Q."Application values of 99mTc‑methoxyisobutylisonitrile imaging for differentiating benign and malignant thymic masses". Oncology Letters 14, no. 2 (2017): 2417-2421. https://doi.org/10.3892/ol.2017.6447