MicroRNAs and cancer: Key paradigms in molecular therapy (Review)

  • Authors:
    • Weige Tan
    • Bodu Liu
    • Shaohua Qu
    • Gehao Liang
    • Wei Luo
    • Chang Gong
  • View Affiliations

  • Published online on: December 19, 2017     https://doi.org/10.3892/ol.2017.7638
  • Pages: 2735-2742
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRNAs) are a type of small non-coding RNA molecule that performs an important role in post‑transcriptional gene regulation. Since miRNAs were first identified in 1993, a number of studies have demonstrated that they act as tumor suppressors or oncogenes in human cancer, including colorectal, lung, brain, breast and liver cancer, and leukemia. Large high‑throughput studies have previously revealed that miRNA profiling is critical for the diagnosis and prognosis of patients with cancer, while certain miRNAs possess the potential to be used as diagnostic and prognostic biomarkers or therapeutic targets in cancer. The present study reviews the studies and examines the roles of miRNAs in cancer diagnosis, prognosis and treatment, and discusses the potential therapeutic modality of exploiting miRNAs.
View Figures
View References

Related Articles

Journal Cover

March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tan W, Liu B, Qu S, Liang G, Luo W and Gong C: MicroRNAs and cancer: Key paradigms in molecular therapy (Review). Oncol Lett 15: 2735-2742, 2018
APA
Tan, W., Liu, B., Qu, S., Liang, G., Luo, W., & Gong, C. (2018). MicroRNAs and cancer: Key paradigms in molecular therapy (Review). Oncology Letters, 15, 2735-2742. https://doi.org/10.3892/ol.2017.7638
MLA
Tan, W., Liu, B., Qu, S., Liang, G., Luo, W., Gong, C."MicroRNAs and cancer: Key paradigms in molecular therapy (Review)". Oncology Letters 15.3 (2018): 2735-2742.
Chicago
Tan, W., Liu, B., Qu, S., Liang, G., Luo, W., Gong, C."MicroRNAs and cancer: Key paradigms in molecular therapy (Review)". Oncology Letters 15, no. 3 (2018): 2735-2742. https://doi.org/10.3892/ol.2017.7638