Open Access

Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer

  • Authors:
    • Yohei Watanabe
    • Motonobu Saito
    • Katsuharu Saito
    • Yoshiko Matsumoto
    • Yasuyuki Kanke
    • Hisashi Onozawa
    • Suguru Hayase
    • Wataru Sakamoto
    • Teruhide Ishigame
    • Tomoyuki Momma
    • Shinji Ohki
    • Seiichi Takenoshita
  • View Affiliations

  • Published online on: December 19, 2017     https://doi.org/10.3892/ol.2017.7650
  • Pages:2756-2762
  • Copyright: © Watanabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Homeobox A (HOXA) cluster genes, members of the HOX family, perform an important role in normal organ development. It has previously been reported that HOXA gene expression in various types of cancer is associated with poor patient outcomes. However, the role of HOXA genes, as well as their expression, in colorectal cancers (CRC) remains unknown. Therefore, the present study investigated HOXA gene expression in patients with CRC and revealed that HOXA9 expression was significantly increased in tumor tissues compared with non‑tumor tissues. Additionally, the functional role of HOXA9 was assessed by knocking down the HOXA9 gene in CRC cells and by evaluating cell growth. Regarding gene expression, cases with positive HOXA9 expression (as detected by immunohistochemical staining) were significantly associated with higher TNM stage and positive lymph node metastasis, although no association was observed between increased HOXA9 levels and the rate of overall survival in the present cohort. Regarding the functional role, HOXA9 expression was demonstrated to be upregulated in patients with CRC and was associated with lymph node metastasis.

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March 2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H. ... Takenoshita, S. (2018). Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer. Oncology Letters, 15, 2756-2762. https://doi.org/10.3892/ol.2017.7650
MLA
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H., Hayase, S., Sakamoto, W., Ishigame, T., Momma, T., Ohki, S., Takenoshita, S."Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer". Oncology Letters 15.3 (2018): 2756-2762.
Chicago
Watanabe, Y., Saito, M., Saito, K., Matsumoto, Y., Kanke, Y., Onozawa, H., Hayase, S., Sakamoto, W., Ishigame, T., Momma, T., Ohki, S., Takenoshita, S."Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer". Oncology Letters 15, no. 3 (2018): 2756-2762. https://doi.org/10.3892/ol.2017.7650