Open Access

Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1

  • Authors:
    • Wenjun Yin
    • Yuehua Nie
    • Lingying Chen
    • Quipping Wang
    • Shuangquan Liu
    • Xiusheng He
    • Wenjun Wang
  • View Affiliations

  • Published online on: December 27, 2017     https://doi.org/10.3892/ol.2017.7690
  • Pages: 2781-2788
  • Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Deregulation of microRNA (miR)‑193b has been revealed to be associated with the proliferation of liver cells. However, the interaction between miR‑193b and their targets inducing liver cancer remains largely unknown. The aim of the present study was to investigate the hypothesis that miR‑193b affects the proliferation of liver cancer cells. In the present study, the overall survival of patients with liver cancer and low fold change of miR‑193b was higher compared with that of patients with liver cancer patients and high fold change of miR‑193b. The expression level of myeloid cell leukemia‑1 (Mcl‑1) in patients with liver cancer was lower compared with in the control group. The results of the present study demonstrated that downregulation of miR‑193b suppressed the proliferation and induced apoptosis of liver cancer cells, and inhibited the Mcl‑1 protein expression level in liver cancer cells. Upregulation of miR‑193b increased cell proliferation and decreased apoptosis of liver cancer cells and promoted the expression level of Mcl‑1 protein. The results of the present study demonstrated that the expression of miR‑193b as a novel tumor suppressor serves an important role in the proliferation of liver cancer cells by mediating Mcl‑1 expression.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yin W, Nie Y, Chen L, Wang Q, Liu S, He X and Wang W: Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1. Oncol Lett 15: 2781-2788, 2018
APA
Yin, W., Nie, Y., Chen, L., Wang, Q., Liu, S., He, X., & Wang, W. (2018). Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1. Oncology Letters, 15, 2781-2788. https://doi.org/10.3892/ol.2017.7690
MLA
Yin, W., Nie, Y., Chen, L., Wang, Q., Liu, S., He, X., Wang, W."Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1". Oncology Letters 15.3 (2018): 2781-2788.
Chicago
Yin, W., Nie, Y., Chen, L., Wang, Q., Liu, S., He, X., Wang, W."Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1". Oncology Letters 15, no. 3 (2018): 2781-2788. https://doi.org/10.3892/ol.2017.7690